Results 121 to 130 of about 1,623,514 (364)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Computational analysis of short-range interactions between an edge dislocation and an array of equally-spaced identical shearable or non-shearable precipitates [PDF]

open access: yesarXiv, 2017
The interaction between dislocations and precipitates plays an important role in the mechanical behavior of alloys. To provide more insight into the physics of this interaction, this research analyzes short-range interactions of an edge dislocation with an array of equally-spaced identical precipitates.
arxiv  

METEOROLOGICAL FEATURES OF EXTREME PRECIPITATION IN THE NORTHERN ADRIATIC [PDF]

open access: yes, 2006
An investigation of extreme precipitation cases in the northern Adriatic area is discussed in this paper. The criterion chosen for an extreme event recognition is a measured daily precipitation amount exceeding 100 mm day-1.
Branka Ivančan-Picek, Tomislav Kozarić
core   +2 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

Overdriven dislocation-precipitate interactions at elevated temperatures in aluminum [PDF]

open access: yesarXiv, 2018
The two-dimensional dislocation dynamics approach has been recently used for analyzing plastic deformation in metals and alloys at elevated temperatures. The two-dimensional approach, however, only accounts for the dislocation climbing process, and it assumes that dislocation bypassing and shearing of precipitates are negligible.
arxiv  

Representing uncertainty in continental-scale gridded precipitation fields for agrometeorological modeling [PDF]

open access: yes, 2008
This work proposes a relatively simple methodology for creating ensembles of precipitation inputs that are consistent with the spatial and temporal scale necessary for regional crop modeling.
Bruin, S., de   +2 more
core   +2 more sources

The diurnal nature of future extreme precipitation intensification [PDF]

open access: yes, 2019
Short‐duration, high‐impact precipitation events in the extratropics are invariably convective in nature, typically occur during the summer, and are projected to intensify under climate change.
Meredith, Edmund P.   +2 more
core   +1 more source

Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell

open access: yesAdvanced Biology, EarlyView.
By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong   +6 more
wiley   +1 more source

The Importance of Humidity in the Afternoon Local-Scale Precipitation Intensity over Eastern China and Its Impacts on the Aerosol Effects

open access: yesRemote Sensing
Thermally driven local-scale precipitation (LSP) is an important type of summer precipitation over China, but the prestorm environmental conditions remain unclear.
Xinlei Tang   +6 more
doaj   +1 more source

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