Results 191 to 200 of about 17,403 (263)

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Changes in temperature and precipitation drive shifts in mean flowering timing of tropical plants from 1960 to 2021 across seven locations. [PDF]

Biol Open
Graves S, Manzitto-Tripp EA.
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Study on the spatiotemporal variation mechanisms of soil moisture in maize fields. [PDF]

Sci Rep
Lan L, Zhang T, Wang B, He F, Wu X, Bao J.   +5 more
europepmc   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Integrated Membrane Filtration for the Recovery of Antioxidants from Lavender Spent Plant Material. [PDF]

Membranes (Basel)
Stoyanova Y, Lazarova-Zdravkova N, Pietsch-Braune S, Petrin S, Stefanova A, Heinrich S, Peshev D.   +6 more
europepmc   +1 more source

Geophysical Retrievals During OLYMPEX/RADEX Using the Advanced Microwave Precipitation Radiometer

, 2020
Corey A. Amoit, Timothy J. Lang, Sayak Biswas, David Duncan   +3 more
openalex   +1 more source

A Reliable Strategy to Unravel the Structure and Composition of Semiconducting Conjugated Donor‐Acceptor Block Copolymers

Advanced Science, EarlyView.
This work proposes a reliable strategy to elucidate the structure and composition of conjugated donor‐acceptor block copolymers. The method, based on NMR analysis, allows to extract key structural information such as the number of heterojunctions (NoH) and the number of blocks (NoB) of the copolymers.
Antoine Curé, Pierre‐Alain Bayle, Lucie Rivet, Yann Kervella, Renaud Demadrille, Cyril Aumaître   +5 more
wiley   +1 more source

Predominantly positive XCO₂ anomalies in the Caatinga biome highlight carbon vulnerability. [PDF]

Sci Rep
Silva LJ, da Costa LM, de Oliveira Bordonal R, Panosso AR, Pereira TTC, Messias CG, La Scala N.   +6 more
europepmc   +1 more source

Added Value of Environmental Variables for Satellite Precipitation Retrieval: A Temporal Coevolution Perspective and a Machine Learning Integration Assessment [PDF]

Runze Li, Clément Guilloteau, Efi Foufoula‐Georgiou   +2 more
openalex   +1 more source