Results 81 to 90 of about 17,403 (263)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Advantages of G-band radar in multi-frequency liquid-phase microphysical retrievals [PDF]

Atmospheric Measurement Techniques
Radar-based microphysical retrievals of cloud and droplet properties are vital for informing model parameterisations of clouds and precipitation, but these retrievals often do not capture the details of small droplets in light rain or drizzle. A state-of-
B. M. Courtier, A. Battaglia, K. Mroz, K. Mroz   +3 more
doaj   +1 more source

Global Precipitation Retrievals Using the NOAA AMSU Millimeter-Wave Channels: Comparisons with Rain Gauges [PDF]

, 2009
Chinnawat Surussavadee, D. H. Staelin
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Accuracy Assessment and Rainfall Intensity Response Mechanisms in GNSS Real‐Time PPP Water Vapor Retrieval: Coupling Effects of Multi‐Source Real‐Time Products and Meteorological Conditions

Earth and Space Science
The Global Navigation Satellite System (GNSS) real‐time Precise Point Positioning (PPP) technology offers a highly efficient approach for atmospheric Precipitable Water Vapor (PWV) monitoring and extreme weather warning.
Wenliang Gao, Guigen Nie, Yu Guo, Jiaqi Shi, Shuguang Wu   +4 more
doaj   +1 more source

A Nowcasting Model for Tropical Cyclone Precipitation Regions Based on the TREC Motion Vector Retrieval with a Semi-Lagrangian Scheme for Doppler Weather Radar

Atmosphere, 2018
Accurate observational data and reliable prediction models are both essential to improve the quality of precipitation forecasts. The spiraling trajectories of air parcels within a tropical cyclone (TC) coupled with the large sizes of these systems brings
Jingyin Tang, Corene Matyas
doaj   +1 more source

A downscaling framework for precipitation nowcasting by merging radar retrievals at different scales and resolutions

, 2021
Roberto Deidda, Stefano Farris, Maria Grazia Badas, Marino Marrocu, Luca Massidda, Alessandro Seoni, Salvatore Urru, Francesco Viola   +7 more
openalex   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source