Results 171 to 180 of about 20,005 (243)

Nanoconfinement‐Steered Molecular Preorganization Enables Efficient Monoethanolamine Degradation through Electronically Modulated High‐Valent Iron–Oxo Pathways

open access: yesAdvanced Science, EarlyView.
Precise modulation of reaction pathways remains an unresolved challenge in peroxymonosulfate‐activated advanced oxidation processes. The spatial preorganization strategy in engineered confinement architecture enables regioselective bond cleavage in monoethanolamine via synergistic proton–electron transfer, redirecting its degradation from nonselective ...
Lin Zhang   +11 more
wiley   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

Niδ+ Atoms Anchored In Situ on Ultrathin Ni‐Phyllosilicate Nanosheet Ensure High‐Efficient CO2 Reduction into CO at Moderate‐Low Temperature

open access: yesAdvanced Science, EarlyView.
A novel supported Ni‐based catalyst, consisting of abundant Niδ+ atoms with low electron density anchored in situ on ultrathin Ni‐phyllosilicate nanosheet (a‐Niδ+−PSNS, 0< δ ≤1), achieve simultaneous outstanding CO2 conversion and CO selectivity. Their ultrathin nanosheet enables abundant anchored Niδ+ atoms to fully expose and disperse, which can ...
Ziluo Ding   +10 more
wiley   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu   +10 more
wiley   +1 more source

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