Results 51 to 60 of about 5,765,436 (248)

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Low-Cost Real-Time PPP/INS Integration for Automated Land Vehicles

Sensors, 2019
The last decade has witnessed a growing demand for precise positioning in many applications including car navigation. Navigating automated land vehicles requires at least sub-meter level positioning accuracy with the lowest possible cost.
Mohamed Elsheikh, Walid Abdelfatah, Aboelmagd Noureldin, Umar Iqbal, Michael Korenberg   +4 more
doaj   +1 more source

A Method to Mitigate the Effects of Strong Geomagnetic Storm on GNSS Precise Point Positioning

Space Weather, 2022
Geomagnetic storm can affect the performance of Global Navigation Satellite System (GNSS) precise positioning services. To mitigate the adverse effects of strong geomagnetic storms, we propose to establish the geometry‐free (GF) cycle slip threshold ...
Xiaomin Luo, Junfeng Du, Yidong Lou, Shengfeng Gu, Xinan Yue, Jingbin Liu, Biyan Chen   +6 more
doaj   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

PENGARUH AKTIVITAS IONOSFER TERHADAP TINGKAT KETELITIAN GPS DENGAN METODE PRECISE POINT POSITIONING (PPP)

, 2016
GPS (Global Positioning System) adalah sistem radio navigasi dan penentuan posisi yang berbasiskan satelit.Saat ini telah berkembang sistem penentuan posisi atau lokasi serta waktu berbasis satelit bernama GNSS (Global Navigation Satellite System ...
Prakoso, Sutopo Yuda
core   +1 more source

Multi-GNSS Single Frequency Precise Point Positioning

, 2018
Single Frequency-Precise Point Positioning (SF-PPP) processing strategy is a hot topic in GNSS context, owing to the advantages of a stand-alone, accurate and cost efficiency positioning. However, the existing SF-PPP methods can be hardly implemented for
Antonio Angrisano, Anna Innac, Angrisano, A, Innac, A, Gaglione, S, Salvatore Gaglione, Gaglione S., Angrisano A., Innac A.   +8 more
core   +1 more source

PPP-RTK : the advantageous result of a hybridization of GNSS accurate positioning techniques [PDF]

, 2021
Precise Global Navigation Satellite system (GNSS) positioning is one of the main keys to outdoor positioning. Different technologies exist, each with its own advantages and disadvantages in terms of performance or robustness.
Isambert, Delphine, Vervisch, Alexandre; orcid:, Chambon, Paul   +2 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Performance of PPP and PPP-RTK with new-generation GNSS constellations and signals

Satellite Navigation
The expansion of Global Navigation Satellite Systems (GNSS) and Regional Navigation Satellite Systems (RNSS), along with broadcasting of additional signals, offers more options for Precise Point Positioning (PPP). Utilizing a number of constellations and
Xiaohong Zhang, Yuhang Yang, Haochen Yang, Xiaodong Ren, Xiaojing Lin, Xuan Le, Xin Li   +6 more
doaj   +1 more source