Results 31 to 40 of about 1,388,009 (200)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Tecnología y ciencias del agua, 2021 En este estudio se realizaron pruebas de linealidad y de precisión, a fin de determinar la demanda química de oxígeno (DQO) en agua para una adaptación a microescala del método de reflujo cerrado a volumen pequeño para rango alto de APHA/AWWA/WEF.
Julio César Morales-Mejía +2 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Geofísica Internacional, 2017 La espectrometría de Fluorescencia de Rayos-X (FRX) es uno de los métodos más usados para medir datos geoquímicos y aplica técnicas tanto destructivas como no destructivas en la preparación de muestras.
Jesús David Quiroz-Jiménez +1 more
doaj +1 more source
Revista de Antropología y Sociología Virajes, 2021 El presente estudio tuvo como objetivo evaluar la exactitud del método Ubelaker y Parra desarrollada en el año 2008, el cual es empleado como estimador de edad en una muestra de población adulta contemporánea extraída de la provincia de Cusco ...
Christian Sebastian Quispe Yupayccana
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Revista Española de Documentación Científica, 2008 En esta nota metodológica se analiza la precisión y exhaustividad de un filtro temático diseñado para delimitar el área de Ciencias del Mar a través de revistas especializadas y palabras clave, y se compara su eficacia con una delimitación basada sólo en
Rodrigo Costas, María Bordons
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source