Results 61 to 70 of about 2,616,182 (244)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Geofísica Internacional, 2017 La espectrometría de Fluorescencia de Rayos-X (FRX) es uno de los métodos más usados para medir datos geoquímicos y aplica técnicas tanto destructivas como no destructivas en la preparación de muestras.
Jesús David Quiroz-Jiménez +1 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Revista Española de Documentación Científica, 2008 En esta nota metodológica se analiza la precisión y exhaustividad de un filtro temático diseñado para delimitar el área de Ciencias del Mar a través de revistas especializadas y palabras clave, y se compara su eficacia con una delimitación basada sólo en
Rodrigo Costas, María Bordons
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
O papel das emoções na relação confiança-exatidão do testemunho
Psicologia USP, 2015 As emoções interferem com a evocação de acontecimentos importantes, afetando a relação confiança-exatidão (C-E) do testemunho. Foi avaliado o impacto das emoções após a visualização de imagens reais de acidentes de trânsito, bem como a sua influência na ...
Maria Anabela Bento Marinho Nunes Reis +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Minería y Geología, 2011 La calidad de la estimación de recursos minerales es uno de los temas más importantes en la industria geológica-minera actual. El desarrollo de los sistemas automatizados en este campo ha permitido un incremento en la calidad de las estimaciones en ...
Orestes Gómez-González +2 more
doaj