Results 61 to 70 of about 2,802,417 (293)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Estimación de la evolución en la adopción de componentes de Agricultura de Precisión de cara al inicio de una década de Agricultura digitalizada [PDF]

, 2020
Con el comienzo de una nueva década el sistema se encuentra en un proceso acelerado de digitalización constante de la agricultura, en plena era de la Agricultura 4.0.
Scaramuzza, Fernando Miguel, Melchiori, Ricardo Jose, Villarroel, Diego Daniel   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Differentiable Soft Quantization: Bridging Full-Precision and Low-Bit Neural Networks [PDF]

IEEE International Conference on Computer Vision, 2019
Hardware-friendly network quantization (e.g., binary/uniform quantization) can efficiently accelerate the inference and meanwhile reduce memory consumption of the deep neural networks, which is crucial for model deployment on resource-limited devices like
Ruihao Gong, Xianglong Liu, Shenghu Jiang, Tian-Hao Li, Peng Hu, Jiazhen Lin, F. Yu, Junjie Yan   +7 more
semanticscholar   +1 more source

Análisis comparativo del levantamiento del terreno mediante UAS y topografía clásica en proyectos de trazado de carreteras

Informes de la Construccion, 2022
La incorporación de vehículos aéreos no tripulados (UAS) como alternativa a los levantamientos topográficos clásicos ha experimentado en estos últimos años un gran avance en todos los ámbitos de la ingeniería, dado que permiten una rápida y eficaz ...
Juan Antonio Pérez, Gil Rito Gonçalves, Jesus Montilla Galván   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fotogrametría de Objeto Cercano: Precisión estimada [PDF]

, 2017
En este artículo se determina la precisión estimada de las coordenadas obtenidas mediante la Fotogrametría de Objeto Cercano, comparándola con la precisión estimada en Fotogrametría Estereoscópica.
Balaguer-Puig, Matilde
core