Results 111 to 120 of about 2,189,833 (270)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

RISK MANAGEMENT POTENTIAL OF PRECISION FARMING TECHNOLOGIES [PDF]

Initial ideas on risk management uses of precision agricultural technology focused on site-specific treatment of problem areas to reduce the probability of low yields and returns.
Lowenberg-DeBoer, James
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Bypassing the imaging thickness limit with a translationally-invariant nonlocal thin film

Nature Communications
Conventional imaging relies on both lenses and free-space propagation. Despite recent advancements, a thickness limit was established for conventional translationally-variant imaging systems based on the nonlocality required for image formation.
Bohan Zhang, Liu Li, Xinyuan Xue, Yibao Xu, Qitong Li, Hao Zhang, Liqun Sun, Liangcai Cao, Yuanmu Yang   +8 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Compensation of Complex Frequency Errors of Voltage Instrument Transformers

, 2018
The paper focuses on a system for the compensation of the frequency response of voltage instrument transformers through the use of a digital filter.
D. Gallo, Crotti, G., M. Luiso, G. Crotti, Luiso, M., D. Giordano, Gallo, D., Giordano, D., Landi, C., C. Landi   +9 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Improved YOLO for long range detection of small drones

Scientific Reports
The timely and accurate detection of unidentified drones is crucial for public safety. However, challenges arise due to background noise in complex environments and limited feature representation of small, distant targets.
Sicheng Zhou, Lei Yang, Huiting Liu, Chongqin Zhou, Jiacheng Liu, Yang Wang, Shuai Zhao, Keyi Wang   +7 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Power management for triboelectric and electrostatic generators enabling continuous and stable power delivery

Nature Communications
Power management is essential for effectively utilizing energy harvested from triboelectric and electrostatic generators. However, current strategies suffer from control and conversion challenges such as inefficient switch designs and load-dependent ...
Zeyuan Cao, Junchi Teng, Yongjia Zhao, Xingqi Guo, Jiani Xu, Chao Ren, Xiongying Ye   +6 more
doaj   +1 more source