Results 111 to 120 of about 164,371 (301)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion

Cell Death and Disease
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with higher histologic grade, poorer prognosis, and fewer treatment options due to the lack of reliable and effective molecular targets. Using a functional approach with
Shiqi Lin, Dongyang Tang, Josh Haipeng Lei, Xiangpeng Chu, Lijian Wang, Kai Miao, Ping Chen, Jingbo Zhou, Aiping Zhang, Ling Li, Heng Sun, Xiaoling Xu, Chuxia Deng   +12 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Collaborative framework on responsible AI in LLM-driven CDSS for precision oncology leveraging real-world patient data

npj Precision Oncology
Precision oncology leverages real-world data, essential for identifying biomarkers and therapies. Large language models (LLMs) can aid at structuring unstructured data, overcoming current bottlenecks in precision oncology.
Sonja Mathes, Dyke Ferber, Tobias Dreyer, Kai J. Borm, Luise Modersohn, Theresa Willem, Richard Dirven, Julien Vibert, Simon Kreutzfeldt, Raquel Perez-Lopez, Arsela Prelaj, Fredrik Strand, Richard D. Baird, Martin Boeker, Jakob Nikolas Kather, Maximilian Tschochohei, Jacqueline Lammert   +16 more
doaj   +1 more source

Data-Driven Methods for Advancing Precision Oncology

, 2018
This article discusses the advances, methods, challenges, and future directions of data-driven methods in advancing precision oncology for biomedical research, drug discovery, clinical research, and practice.
Georg Gutjahr, Jasmine Bhaskar, Gutjahr, Georg, Prema Nedungadi, Iyer, Akshay, Pillai, Asha B, Asha B. Pillai, Akshay Iyer, Bhaskar, Jasmine, Nedungadi, Prema   +9 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

How life-cycle real-world evidence can bridge evidentiary gaps in precision oncology

Frontiers in Medicine
Precision oncology uses omics-based diagnostic technologies to inform histology-agnostic cancer treatment. To date, health system implementation remains limited owing to high uncertainty in regulatory and reimbursement evidence submissions.
Emanuel Krebs, Deirdre Weymann, Deirdre Weymann, Tania Bubela, Tania Bubela, Dean A. Regier, Dean A. Regier   +6 more
doaj   +1 more source

Delivering precision oncology to patients with cancer

, 2022
With the increasing use of genomic profiling for diagnosis and therapy guidance in many tumor types, precision oncology is rapidly reshaping cancer care.
Reis-Filho, Jorge S., Husereau, Don, Normanno, Nicola, Westphalen, C. Benedikt, Martinez-Lopez, Iciar, Garralda, Elena, Thomas, David M., André, Fabrice, Aftimos, Philippe, Stefani, Stephen, Voest, Emile, Geissler, Jan, Davies, Mark, Steuten, Lotte, Mateo, Joaquin   +14 more
core  

The Emergence of Precision Urologic Oncology: A Collaborative Review on Biomarker-driven Therapeutics [PDF]

, 2017
CONTEXT: Biomarker-driven cancer therapy, also referred to as precision oncology, has received increasing attention for its promise of improving patient outcomes by defining subsets of patients more likely to respond to various therapies. OBJECTIVES:
Chinnaiyan, AM, Chinnaiyan, Arul M, Swanton, C, Lerner, Seth P, Rubin, Mark Andrew, Lerner, SP, Barbieri, CE, Rubin, MA, Barbieri, Christopher E, Swanton, Charles   +9 more
core   +1 more source