Results 141 to 150 of about 164,371 (301)

Precision oncology revolution: CRISPR-Cas9 and PROTAC technologies unleashed

Frontiers in Genetics
Cancer continues to present a substantial global health challenge, with its incidence and mortality rates persistently reflecting its significant impact.
Karim Kanbar, Karim Kanbar, Roy El Darzi, Roy El Darzi, Diana E. Jaalouk   +4 more
doaj   +1 more source

Precision oncology: neither a silver bullet nor a dream

, 2017
Precision oncology is not an illusion, nor is it the magic bullet that will eradicate all cancers. Precision oncology is simply another weapon in our growing armament against cancer. Rather than honing in on the failures of a relatively young field, one
Nora S Sánchez, Kenna R Mills Shaw, Gordon B Mills   +2 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Precision Oncology: Another Tower of Babel?

healthbook TIMES. Oncology Hematology, 2022
Nicolas Bonadies
doaj   +1 more source

Molecular and modular intricacies of precision oncology

Frontiers in Immunology
Precision medicine is revolutionizing the world in combating different disease modalities, including cancer. The concept of personalized treatments is not new, but modeling it into a reality has faced various limitations.
Ravneet Chhabra
doaj   +1 more source

Precision oncology through next generation sequencing in hepatocellular carcinoma. [PDF]

Hepatocellular carcinoma (HCC) is a primary liver cancer that originates from underlying inflammation, often associated with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infections.
Shinde, Sayali, Caglayan, Aydin, Kathuria, Nikita, Apte, Vedika, Simmons, Ana, Lapitan, Patricia, Makker, Shania, Ghose, Aruni, Bigogno, Carola Maria, Boussios, Stergios   +9 more
core   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies

, 2018
Purpose: The promise of precision oncology is that identification of genomic alterations will direct the rational use of molecularly targeted therapy.
Shyr, Yu, Stephens, Phil J., Miller, Vincent A., Guo, Yan, Davé, Utpal P., Irish, Jonathan M., Kozhaya, Lina, Palma, Norma, Chen, Xueyan, Greenplate, Allison, Tripathi, Rati M., Unutmaz, Derya, Reddy, Nishitha M., Wang, Kai, Ali, Siraj M.   +14 more
core   +1 more source