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Impact of Precision Medicine in Oncology
The Cancer Journal, 2023Abstract Cancer treatment has dramatically changed over the last decade with the development of immunotherapy. Therapies including immune cytokines, immune checkpoint inhibition, intratumoral therapies, and cellular therapies are already widely used in the oncology clinic.
Elizabeth I, Buchbinder, F Stephen, Hodi
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Nature, 2020
Precision medicine broadly refers to both the science and practice of medicine that can be personalized to an individual patient level. The clinical applications of precision medicine have gradually and meaningfully followed related scientific and technological advances.
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Precision medicine broadly refers to both the science and practice of medicine that can be personalized to an individual patient level. The clinical applications of precision medicine have gradually and meaningfully followed related scientific and technological advances.
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Precision in radiation oncology
International Journal of Radiation Oncology*Biology*Physics, 1982The practice of medicine demands as much or more precision and exactness as any other human endeavor. This relates to the importance of the outcome to the patient and the intolerance of errors by both the patient and the judicial system. In all of medical practice, the outcome relates to the effective delivery of treatment. The successful operation and
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Precision Endpoints for Contemporary Precision Oncology Trials
Cancer DiscoverySummary: Traditional endpoints such as progression-free survival and overall survival do not fully capture the pharmacologic and pharmacodynamic effects of a therapeutic intervention. Incorporating mechanism-driven biomarkers and validated surrogate proximal endpoints can provide orthogonal readouts of anti-tumor ...
Regina Hoo +4 more
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The Future of Precision Medicine in Oncology
Clinics in Laboratory Medicine, 2016Precision medicine in oncology focuses on identifying which therapies are most effective for each patient based on genetic characterization of the cancer. Traditional chemotherapy is cytotoxic and destroys all cells that are rapidly dividing. The foundation of precision medicine is targeted therapies and selecting patients who will benefit most from ...
Lori M, Millner, Lindsay N, Strotman
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Precision Oncology: 2024 in Review
Cancer DiscoverySummary: This article discusses the specific advances made in precision oncology in 2024. We comment on the evolving nature of predictive molecular events used to select patients who will most benefit clinically from treatment.
Matteo Repetto +3 more
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Measuring Progress in Precision Oncology
Cancer DiscoverySummary: In this issue of Cancer Discovery, Suehnholz and colleagues describe their efforts to quantify the gradual yet steady progress of precision oncology by surveying the regulatory approvals of targeted cancer therapies, and thus the actionability of corresponding molecular alterations in clinical practice ...
Peter Horak, Stefan Fröhling
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Network Approaches for Precision Oncology
2022The growth of multi-omic tumour profile datasets along with knowledge of genome regulatory networks has created an unprecedented opportunity to advance precision oncology. Achieving this goal requires computational methods that can make sense of and combine heterogeneous data sources. Interpretability and integration of prior knowledge is of particular
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Precision Oncology: 2025 in Review
Cancer DiscoverySummary: This article discusses the specific advances made in precision oncology in 2025, in which we saw the approval of multiple new indications for known precision oncology agents and early promising data for novel agents that target either classical pathways or previously so-called undruggable targets.
Nicholas Mai +3 more
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