Results 91 to 100 of about 789,487 (311)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Overview of preclinical study outcomes.
, 2021 Overview of preclinical study outcomes.
Maarten Albersen (4566958) +4 more
core +1 more source
Cuban policosanol: a natural compound for ischemic stroke treatment
Exploration of NeuroscienceStroke is among the leading causes of mortality and disability; therefore, it constitutes a relevant health problem. Cuban policosanol presents lipid-lowering, antiplatelet, antioxidant and vascular endothelium protective properties, all of which give it
Vivian Molina Cuevas +1 more
doaj +1 more source
Quantitative preclinical PET imaging: opportunities and challenges
Frontiers in Physics, 2014 PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the ...
Claudia eKuntner, David B Stout
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Frontiers in Psychiatry, 2011 Addiction represents a complex interaction between the reward and stress neural circuits, with increasing drug use reflecting a shift from positive reinforcement to negative reinforcement mechanisms in sustaining drug dependence. Preclinical studies have
Helena eRutherford +6 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
CellsSexual dimorphism of visceral pain has been documented in clinics and experimental animal models. Aside from hormones, emerging evidence suggests the sex-differential intrinsic neural regulation of pain generation and maintenance.
Namrata Tiwari, Liya Y. Qiao
doaj +1 more source
Investigating Grey Matter Network Alterations in Preclinical Alzheimer's Disease Using Graph Theoretical Measures [PDF]
openAlzheimer’s Disease (AD) is the leading cause of dementia. Given the growing number of older population, it becomes a concerning healtcare issue. The brain begins to deteriorate several years before the emergence of clinical symptoms.
HARPUT, ELIF
core
, 2023 Jianmin Li,1,2,* Wenyi Zhang,1,2,* Shuang Liu,1,2,* Fan Yang,2 Yupeng Zhou,2 Lin Cao,1,2 Yiming Li,1,2 Yunfei Guo,1,2 Xiang Qi,1,2 Guoping Xu,1 Jing Peng,1 Yang Zhao1,2 1Department of Radiology, The Second Hospital of Tianjin Medical ...
Zhang W +11 more
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