Results 91 to 100 of about 714,050 (315)

Preclinical Evaluation of a Protein-Based Nanoscale Contrast Agent for MR Angiography at an Ultralow Dose

open access: yes, 2023
Jianmin Li,1,2,* Wenyi Zhang,1,2,* Shuang Liu,1,2,* Fan Yang,2 Yupeng Zhou,2 Lin Cao,1,2 Yiming Li,1,2 Yunfei Guo,1,2 Xiang Qi,1,2 Guoping Xu,1 Jing Peng,1 Yang Zhao1,2 1Department of Radiology, The Second Hospital of Tianjin Medical ...
Zhang W   +11 more
core  

A systematic literature review of assessment feedback in preclinical dental education

open access: yes, 2020
INTRODUCTION: Development of evaluative judgement abilities through assessment and feedback strategies are crucial in students' progress to become self-regulated life-long learners.
Roy George   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Proposed strategies for preclinical researchers.

open access: yes, 2023
Proposed strategies for preclinical researchers.
Victoria T. Hunniford (10751750)   +11 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques

open access: yesBiomedicines, 2016
Anti-cancer immunotherapy is emerging from a nadir and demonstrating tangible benefits to patients. A variety of approaches are now employed. We are invoking antigen (Ag)-specific responses through direct injections of recombinant lentivectors (LVs) that
Bryan C. Au   +13 more
doaj   +1 more source

Cuban policosanol: a natural compound for ischemic stroke treatment

open access: yesExploration of Neuroscience
Stroke is among the leading causes of mortality and disability; therefore, it constitutes a relevant health problem. Cuban policosanol presents lipid-lowering, antiplatelet, antioxidant and vascular endothelium protective properties, all of which give it
Vivian Molina Cuevas   +1 more
doaj   +1 more source

Quantitative preclinical PET imaging: opportunities and challenges

open access: yesFrontiers in Physics, 2014
PET imaging of metabolism involves many choices, from hardware settings, software options to animal handling considerations. How to decide what settings or conditions to use is not straightforward, as the experimental design is dependent on the ...
Claudia eKuntner, David B Stout
doaj   +1 more source

Prevalence and risk factors of stress, anxiety and depression among preclinical medical students in Universiti Putra Malaysia in 2014 [PDF]

open access: yes, 2015
Aims: To determine the prevalence and risk factors of stress, anxiety, and depression among preclinical medical students of Universiti Putra Malaysia in 2014. Settings and Design: Cross sectional study design was used.
Ibrahim, Normala   +4 more
core  

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