Results 331 to 340 of about 1,044,728 (382)
Some of the next articles are maybe not open access.
Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs
Pharmacology & Therapeutics, 1993Forty years after the first clinical report on the effectiveness of chlorpromazine in psychiatric patients, neuroleptic drugs are still the most widely used drugs in the treatment of schizophrenia. Indeed, there are no other drugs which have proven to be as effective in the treatment of this severe psychiatric disorder.
openaire +3 more sources
Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation
Journal of Pharmacological and Toxicological Methods, 2005The human ether-a-go-go-related gene (hERG) potassium channel plays a major role in the electrical conductances involved in human heart repolarization. Drugs that decrease hERG K(+) currents are at risk to produce a prolongation of the cardiac action potential, resulting in an increase of the QT interval.
Liang Guo, Heather Guthrie
openaire +2 more sources
Drug Discovery Today, 2023
The formation of reactive metabolites (RMs) is thought to be one of the pathogeneses for some idiosyncratic adverse drug reactions (IADRs) which are considered one of the leading causes of some drug attritions and/or recalls. Minimizing or eliminating the formation of RMs via chemical modification is a useful tactic to reduce the risk of IADRs and time-
Chunyong, He, Yuchang, Mao, Hong, Wan
openaire +2 more sources
The formation of reactive metabolites (RMs) is thought to be one of the pathogeneses for some idiosyncratic adverse drug reactions (IADRs) which are considered one of the leading causes of some drug attritions and/or recalls. Minimizing or eliminating the formation of RMs via chemical modification is a useful tactic to reduce the risk of IADRs and time-
Chunyong, He, Yuchang, Mao, Hong, Wan
openaire +2 more sources
The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation
Drug Information Journal, 1998Pharmacokinetic drug-drug interactions (PDDI), in which the pharmacokinetic clearance of one drug is altered by a coadministered drug, can be divided mechanistically into two general categories: 1. Inhibitory PDDI—the inhibition of the metabolic clearance of one drug by a coadministered drug, and 2.
openaire +2 more sources
Preclinical evaluation of behavioral deficits following hypnotic drug treatment
Pharmacology Biochemistry and Behavior, 1986Most hypnotic medications result in performance decrements, or "hangover effects," the morning after bedtime ingestion. However, the severity of hangover effects with new compounds is difficult to predict prior to clinical trials. This paper describes a preclinical procedure that is predictive of human hangover effects following bedtime ingestion of ...
Louis C. Iorio +2 more
openaire +3 more sources
EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
Radiotherapy and Oncology, 2007Preclinical and clinical results indicate that the EGFR can mediate radioresistance in different solid human tumours. Combination of radiotherapy and EGFR inhibitors can improve local tumour control compared to irradiation alone and has been introduced into clinical radiotherapy practice.
Michael Baumann +6 more
openaire +2 more sources
ChemInform Abstract: Drug Safety Evaluation at the Preclinical Stage
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire +2 more sources
Expert Opinion on Drug Discovery, 2011
There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span, maintaining normal physiological function, and alleviating the onset and severity of age-associated diseases. This review looks at the current screening approaches used to evaluate the efficacy of such
Peter А Egormin +14 more
openaire +2 more sources
There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span, maintaining normal physiological function, and alleviating the onset and severity of age-associated diseases. This review looks at the current screening approaches used to evaluate the efficacy of such
Peter А Egormin +14 more
openaire +2 more sources
Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs
2005Type I and II DNA topoisomerases are the targets for numerous clinically efficacious antitumor agents. Over the last decade, considerable effort has been expended in developing camptothecin (CPT) derivatives that selectively target DNA topoisomerase I (TOP-I) (1).
Clinton F. Stewart +4 more
openaire +2 more sources
Evaluation of Antiseptic Drug Candidate Pyridosept in Preclinical in Vitro Studies
Current Medicinal ChemistryIntroduction: This work provides preclinical in vitro studies of an innovative antimicrobial agent named pyridosept, belonging to the quaternary bis-ammonium salts and synthesized on the base of pyridoxine. Since the wide spread of pathogens with tolerance to both antibiotics and antiseptics challenges the development of new antimicrobials providing ...
Renata Kazakova +20 more
openaire +2 more sources