Results 181 to 190 of about 6,725,081 (364)

Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia [PDF]

, 2007
Ivana Cecić, Denise A. Chan, Patrick D. Sutphin, Pritha Ray, Sanjiv S. Gambhir, Amato J. Giaccia, Edward E. Graves   +6 more
openalex   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Feasibility of in vivo small animal imaging using a clinical total-body PET/CT system

EJNMMI Physics
Background Clinical PET scanners have long been explored for preclinical imaging, but limited spatial resolution and sensitivity have restricted their use for preclinical studies.
Julia G. Mannheim, Wenhong Lan, Maurizio Conti, Franziska Siedler, Marcel A. Krueger, Kristina Herfert, Christian la Fougère, Fabian P. Schmidt   +7 more
doaj   +1 more source

Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies. [PDF]

Front Med (Lausanne), 2021
Dagallier C, Avry F, Touchefeu Y, Buron F, Routier S, Chérel M, Arlicot N.   +6 more
europepmc   +1 more source

Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models [PDF]

, 2021
Fokko J. Huizing, Bianca A.W. Hoeben, Jasper Lok, Otto C. Boerman, Sandra Heskamp, Johan Bussink   +5 more
openalex   +1 more source

Ultrasonography Compared With Computed Tomography in Identifying Thoracic Aortic Aneurysms in Patients With Giant Cell Arteritis

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to evaluate the correlation and agreement between ultrasonography and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA.
Anne C. Bull Haaversen, Lene K. Brekke, Tanaz A. Kermani, Øyvind Molberg, Andreas P. Diamantopoulos   +4 more
wiley   +1 more source

Evaluating methodological constraints in PET imaging of neuropeptide Y2 receptors with N-[11C]-methyl-(R)-JNJ-31020028 in brains of C57BL/6J mice

EJNMMI Radiopharmacy and Chemistry
Background The Neuropeptide Y (NPY) system regulates mood, stress, and feeding behavior and plays a central role in neuropsychiatric and metabolic disorders.
Karsten Bamminger, Eduardo Felipe Alves Fernandes, Lena Zachhuber, Ines Lopez-Martinez, Claudia Kuntner, Oliver Langer, Severin Mairinger, Berit Ø. Christoffersen, Marcus Hacker, Thomas Wanek   +9 more
doaj   +1 more source

Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment. [PDF]

Int J Radiat Oncol Biol Phys, 2022
Brooks J, Zuro D, Song JY, Madabushi SS, Sanchez JF, Guha C, Kortylewski M, Chen BT, Gupta K, Storme G, Froelich J, Hui SK.   +11 more
europepmc   +1 more source