Results 201 to 210 of about 6,725,081 (364)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Noninvasive in vivo deoxycytidine kinase (dCK)-PET identifies tumor-draining lymph nodes upon immune checkpoint inhibitor therapy

npj Imaging
Efficient application of immunotherapy necessitates advanced whole-body imaging techniques to monitor sites of immune cell activation. Deoxycytidine kinase (dCK), a key enzyme in the deoxynucleotide salvage pathway, is upregulated in proliferating immune
Cécile Philippe, Jonathan Cotton, Gregory D. Bowden, Simone Pöschel, Philipp Knopf, Barbara Schörg, Irene Gonzalez-Menendez, Dominik Sonanini, Lukas Flatz, Martin Allen-Auerbach, Caius G. Radu, Johannes Czernin, Leticia Quintanilla-Martinez, Marcus Hacker, Bernd J. Pichler, Andreas Maurer, Manfred Kneilling   +16 more
doaj   +1 more source

Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models

, 2016
Brooks D. Lindsey, Sarah E. Shelton, F. Stuart Foster, Paul A. Dayton   +3 more
openalex   +1 more source

0321: Applications and Contrast Imaging with Micro-Ultrasound in Preclinical Cancer and Cardiovascular Research [PDF]

, 2009
F. Stuart Foster
openalex   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Imaging technologies for preclinical models of bone and joint disorders [PDF]

, 2011
Jordi L. Tremoleda, Magdy M. Khalil, Luke Gompels, Marzena Wylezinska‐Arridge, Tonia L. Vincent, Willy Gsell   +5 more
openalex   +1 more source

Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects

Journal of Nuclear Medicine, 2017
J. Joseph, M. Tomaszewski, I. Quiros-Gonzalez, Judith Weber, J. Brunker, S. Bohndiek   +5 more
semanticscholar   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

A Fluorescent Probe as a Lead Compound for a Selective α‑Synuclein PET Tracer: Development of a Library of 2‑Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB

ACS Omega, 2023
Adriana Di Nanni, Ran Sing Saw, Umberto M. Battisti, Gregory D. Bowden, Adam Boeckermann, Kaare Bjerregaard-Andersen, Bernd J. Pichler, Kristina Herfert, Matthias M. Herth, Andreas Maurer   +9 more
doaj   +1 more source