Results 211 to 220 of about 6,451,122 (364)

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Novel System for Real-Time Integration of 3-D Echocardiography and Fluoroscopy for Image-Guided Cardiac Interventions: Preclinical Validation and Clinical Feasibility Evaluation [PDF]

, 2014
Aruna Arujuna, R. James Housden, YingLiang Ma, Ronak Rajani, Gang Gao, Niels Nijhof, Pascal Cathier, Roland Bullens, Geert H. M. Gijsbers, Victoria Parish, Stamatis Kapetanakis, Jane Hancock, Christopher A. Rinaldi, Michael Cooklin, Jaswinder Gill, Martyn Thomas, Mark O’Neill, Reza Razavi, Kawal Rhode   +18 more
openalex   +1 more source

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis

Advanced Healthcare Materials, EarlyView.
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu, Joel M. Yong, Robyn Yeh, Florence Bartlett, John M. Whitelock, Megan S. Lord   +5 more
wiley   +1 more source

Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source. [PDF]

Sci Rep
Peñas J, Alejo A, Bembibre A, Apiñaniz JI, García-García E, Guerrero C, Henares JL, Hernández-Palmero I, Méndez C, Millán-Callado MÁ, Puyuelo-Valdés P, Seimetz M, Benlliure J.   +12 more
europepmc   +1 more source

Preclinical Characterization of 5-Amino-4-Oxo-[6-¹¹C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid [PDF]

, 2014
Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Maki Okada, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano, Tsuneo Saga   +9 more
openalex   +1 more source

Mandibular Implants: A Metamaterial‐Based Approach to Reducing Stress Shielding

Advanced Healthcare Materials, EarlyView.
Metamaterial mandibular implants offer a novel approach to reducing stress shielding and enhancing biomechanical stimulation. This study compares a gyroid‐based metamaterial plate to a solid titanium plate using photoelasticity and finite element analysis.
Jorn‐Ids Heins, Bram B.J. Merema, Joep Kraeima, Max J.H. Witjes, Anastasiia O. Krushynska   +4 more
wiley   +1 more source

Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy

, 2012
Honey V. Reddi, Pranathi Madde, Samantha J. McDonough, María A. Trujillo, John C. Morris, Rae Myers, Kah-Whye Peng, Stephen J. Russell, Bryan McIver, Norman L. Eberhardt   +9 more
openalex   +1 more source

P4‐143: PROGRESSION OF PRECLINICAL ALZHEIMER'S DISEASE ASSOCIATED WITH AMYLOID PET AND FDG PET IMAGING [PDF]

, 2014
Shizuo Hatashita, Hidetomo Yamasaki, Daichi Wakebe   +2 more
openalex   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Automated radiosynthesis and preclinical imaging of a novel [¹⁸F]fluorolidocaine analogue via sequential C-H radiolabelling. [PDF]

RSC Med Chem
Frazier M, Wright JS, Raffel DM, Stauff J, Winton WP, Scott PJH, Brooks AF.   +6 more
europepmc   +1 more source