Results 221 to 230 of about 6,451,122 (364)

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Toward Quantitative Multisite Preclinical Imaging Studies in Acute Myocardial Infarction: Evaluation of the Immune-Fibrosis Axis. [PDF]

J Nucl Med
Strunk M, Heo GS, Hess A, Luehmann H, Ross TL, Gropler RJ, Bengel FM, Liu Y, Thackeray JT.   +8 more
europepmc   +1 more source

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures [PDF]

, 2015
Franziska E. Uhl, Sarah Vierkotten, Darcy E. Wagner, Gerald Burgstaller, Rita Costa, Ina Koch, Michael Lindner, Silke Meiners, Oliver Eickelberg, Mélanie Königshoff   +9 more
openalex   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in Mice [PDF]

, 2015
MG Kaul, O. Weber, Ulrich Heinen, Aline Reitmeier, Tobias Mummert, Caroline Jung, Nina Raabe, Tobias Knopp, Harald Ittrich, Gerhard Adam   +9 more
openalex   +1 more source

Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications

Advanced Materials, EarlyView.
A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung, Jamal Abu Shihada, Simon Decke, Lina Koschinski, Peter Severin Graff, Sebastián Maruri Pazmino, Anke Höllig, Henner Koch, Simon Musall, Andreas Offenhäusser, Viviana Rincón Montes   +10 more
wiley   +1 more source

Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging

Clinical and translational imaging, 2020
Jay S. Wright, Tanpreet Kaur, Sean M. Preshlock, Sean S. Tanzey, Wade P. Winton, Liam S. Sharninghausen, Nicholas Wiesner, Allen F. Brooks, M. Sanford, P. Scott   +9 more
semanticscholar   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Preclinical ultrasound image-guided high intensity focused ultrasound robot system for breast cancer therapy [PDF]

, 2015
Takashi Azuma, Ryusuke Sugiyama, Kazuhiro Matsui, Keisuke Fujiwara, Hideki Takeuchi, Kazunori Itani, Kiyoshi Yoshinaka, Akira Sasaki, Shu Takagi, Ichiro Sakuma, Yoichiro Matsumoto, Toshihide Iwahashi   +11 more
openalex   +1 more source