Results 281 to 290 of about 6,725,081 (364)

The application of in vivo and ex vivo multispectral epi-fluorescence imaging for the preclinical discovery and development of monoclonal antibodies in tumor xenograft models

, 2014
Michael Dobosz
openalex   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Synthesis and Preclinical Evaluation of Sulfonamido-based [¹¹C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase

, 2016
Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H. Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming‐Rong Zhang, Steven H. Liang   +17 more
openalex   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla Iglesias García, Jagoda Litowczenko‐Cybulska, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts. [PDF]

J Med Imaging (Bellingham), 2017
Dillenseger JP, Goetz C, Sayeh A, Healy C, Duluc I, Freund JN, Constantinesco A, Aubertin-Kirch G, Choquet P.   +8 more
europepmc   +1 more source

Preclinical magnetic resonance imaging of proinflammatory epicardial adipose tissue: accelerated methods for simultaneous fatty acid composition and relaxation parameter mapping with relationships to tissue biomarkers

Julia Bresticker, Caitlin Pavelec, John T. Echols, Amit R. Patel, Matthew J. Wolf, Frederick H. Epstein   +5 more
openalex   +1 more source

Design, Synthesis and Preclinical Evaluation of a Novel PET Tracer for P2Y12R Imaging in the Brain [PDF]

Emanuel Joseph, Lea H. Kunze, Rebecca Schaefer, Giovanna Palumbo, Benjamin Kugelmann, Stephan Wagner, Sven Lammich, Regina Feederle, Michael Willem, Rudolf A. Werner, Matthias Brendel, Simon Lindner   +11 more
openalex   +1 more source

Radiation Effects in Electret Organic Thin‐Film Transistors Due to High Flux and High Dose X‐Ray Irradiation

Advanced Materials, EarlyView.
Electret‐style organic thin‐film transistors are evaluated for synchrotron X‐ray dosimetry at ultra‐high dose rates, showing promising performance and agreement with standard detectors. XPS and NEXAFS reveal radiation‐induced oxidation and Fermi level shifts in pentacene and polystyrene, correlating with reduced charge carrier mobility and providing ...
Alexandria Mitchell, Jessie A. Posar, James Cayley, Georgia York, Michael Lerch, Attila J. Mozer, Igor Píš, Elena Magnano, Luca Tosti, Maddalena Pedio, Alasdair Syme, Ian G. Hill, Marco Petasecca   +12 more
wiley   +1 more source