Results 291 to 300 of about 6,451,122 (364)

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

Advanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová, Francisco Javier Rodriguez‐Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Ana Artero‐Castro, Ruslan Nyshchuk, Anastasiia Kolesnikova, Brigitte Müller, Hana Studenovska, Jana Juhasova, Stefan Juhas, Ivona Valekova, Dunja Lukovic, Claudia Aleman, Taras Ardan, Saskia Drutovič, Jan Motlik, Zdenka Ellederova, Zbinek Straňák, Miroslav Veith, Lyubomyr Lytvynchuk, Ruchi Sharma, Kapil Bharti, Goran Petrovski, Pavla Jendelova, Knut Stieger, Slaven Erceg   +27 more
wiley   +1 more source

Quantification of perforant path fibers for early detection of Alzheimer's disease. [PDF]

Alzheimers Dement
Uchida Y, Hou Z, Gomez-Isaza L, Luongo M, Troncoso JC, Miller MI, Mori S, Oishi K.   +7 more
europepmc   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Theranostics in Hematological Malignancies: Cutting-Edge Advances in Diagnosis and Targeted Therapy. [PDF]

Cancers (Basel)
Bogdanovic B, Hugonnet F, Montemagno C.
europepmc   +1 more source

Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control

Advanced Science, EarlyView.
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui, Wonjoon Moon, Pu‐Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey A. Gelfand, Seok‐Hyun Yun   +12 more
wiley   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Exploring the diagnostic potential: magnetic particle imaging for brain diseases. [PDF]

Mil Med Res
Guo LS, An Y, Zhang ZY, Ma CB, Li JQ, Dong Z, Tian J, Liu ZY, Liu JG.   +8 more
europepmc   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Evaluation of Suprachoroidal Injection in Cadaveric and Preclinical Models. [PDF]

Transl Vis Sci Technol
Hedgeland M, Camacho Gonzalez S, Stampoulis D, Lee V, Powell K, Qiu Y, Hodge R, Bell G, Fago A, Atkinson-Dell R, Choti N, Stoner K.   +11 more
europepmc   +1 more source

Optical (Cherenkov) dosimetry to unravel the radiobiological effects of radioisotope based therapy. [PDF]

Eur J Nucl Med Mol Imaging
Van Leeuwen FWB, Pouget JP, Lassmann M.
europepmc   +1 more source