Results 311 to 320 of about 6,451,122 (364)

Preclinical Imaging in Targeted Cancer Therapies

Seminars in Nuclear Medicine, 2019
Preclinical imaging with radiolabeled probes can provide noninvasive tools to test the efficacy of targeted agents in tumors harboring specific genetic alterations and to identify imaging parameters that can be used as pharmacodynamics markers in cancer patients. The present review will primarily focus on preclinical imaging studies that can accelerate
Iommelli Francesca, De Rosa Viviana, Terlizzi Cristina, Fonti Rosa, Del Vecchio Silvana   +4 more
openaire   +5 more sources

Preclinical Imaging of siRNA Delivery

Australian Journal of Chemistry, 2016
Small interfering RNA (siRNA) is emerging as a class of therapeutic with extremely high potential, particularly in the field of oncology. Despite this growing interest, further understanding of how siRNA behaves in vivo is still required before significant uptake into clinical application.
Fletcher, Nicholas, Ardana, Aditya, Thurecht, Kristofer J.   +2 more
openaire   +3 more sources

Preclinical imaging in oncology: advances and perspectives

The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2017
Preclinical imaging with radiolabeled probes became an integral part of the complex translational process that moves a newly developed compound from laboratory to clinical application. Imaging studies in animal tumor models may be undertaken to test a newly synthesized tracer, a newly developed drug or to interrogate, in the living organism, specific ...
Iommelli Francesca, De Rosa Viviana, Terlizzi Cristina, Del Vecchio Silvana   +3 more
openaire   +5 more sources

Preclinical Imaging in Bone Tissue Engineering

Tissue Engineering Part B: Reviews, 2014
Since X-rays were discovered, in 1895, and since the first radiological image of a hand, bone tissue has been the subject of detailed medical imaging. However, advances in bone engineering, including the increased complexity of implant scaffolds, currently also underline the limits of X-ray imaging.
Ventura, M., Boerman, O.C., de Korte, C.L., de Korte, C.L., Rijpkema, M.J.P., Heerschap, A., Oosterwijk, E., Jansen, J.A., Walboomers, X.F.   +8 more
openaire   +4 more sources

Challenges in Imaging in Preclinical Rheumatoid Arthritis

Rheumatic Disease Clinics of North America, 2014
There exists a preclinical phase to the disease progression of rheumatoid arthritis, in which there is evidence of autoimmunity but no overt clinical arthritis. Identifying patients in this phase would allow for early treatment, to potentially halt manifestation of the disease.
Daniel P. Marcusa, Lisa A. Mandl
openaire   +3 more sources

A review of polarization-based imaging technologies for clinical and preclinical applications

Journal of Optics, 2020
Polarization-based imaging can provide new diagnostic capabilities in clinical and preclinical studies. Various methodologies of increasing complexity have been proposed by different groups in the last 30 years. In this review we focus on the most widely
J. Ramella-Roman, I. Saytashev, M. Piccini   +2 more
semanticscholar   +1 more source

Harnessing the potential of noninvasive in vivo preclinical imaging of the immune system: challenges and prospects.

Nanomedicine, 2016
Preclinical imaging has become a powerful method for investigation of in vivo processes such as pharmacokinetics of therapeutic substances and visualization of physiologic and pathophysiological mechanisms.
M. Diken, S. Pektor, M. Miederer
semanticscholar   +1 more source

Preclinical imaging for targeting cancer immune evasion

The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2020
Novel anticancer immunotherapy strategies such as immune checkpoint blockade have been successfully employed in patients with a variety of cancers and became a therapeutic option in the treatment of several malignancies. However, long-term durable responses to immune checkpoint inhibitors are currently limited to a fraction of patients raising the need
Terlizzi C, De Rosa V, Iommelli F, Altobelli GG, Fonti R, Del Vecchio S   +5 more
openaire   +4 more sources

Technologies: preclinical imaging for drug development

Drug Discovery Today: Technologies, 2013
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography (CT), ultrasound (US), positron emission tomography (PET) or single-photon emission computed tomography (SPECT) enable non-invasive measures of tissue structure, function or metabolism in vivo.
Robert W. Coatney, Sharon Ashworth, Kumar Changani, Paul M. Matthews, Paul M. Matthews, Christine A. Parker, Beat M. Jucker, Hasan Alsaid   +7 more
openaire   +3 more sources

Imaging in Clinical and Preclinical Practice

2017
Over the years, medical imaging has become an inherent part of modern medicine and biomedical engineering. Various imaging methods, which provide the detailed insight into human body interior, are widely used in clinical and preclinical practice. They enable the accurate diagnosis of complex pathological states, planning and performing of challenging ...
Sladjana Petrovic, Nikola Korunović
openaire   +2 more sources