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Preclinical imaging for targeting cancer immune evasion
The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2020Novel anticancer immunotherapy strategies such as immune checkpoint blockade have been successfully employed in patients with a variety of cancers and became a therapeutic option in the treatment of several malignancies. However, long-term durable responses to immune checkpoint inhibitors are currently limited to a fraction of patients raising the need
Terlizzi C +5 more
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Preclinical Optical Molecular Imaging
2014Molecular imaging, especially small-animal preclinical molecular imaging, is a rapidly developing area in the biomedical imaging field [1–3]. Given tremendous needs in biological research and drug development, it becomes imperative to have in vivo imaging strategies for gene expression, protein interactions, and cell behaviours [4].
Yujie Lu, Ge Wang
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A review of polarization-based imaging technologies for clinical and preclinical applications
Journal of Optics, 2020Polarization-based imaging can provide new diagnostic capabilities in clinical and preclinical studies. Various methodologies of increasing complexity have been proposed by different groups in the last 30 years. In this review we focus on the most widely
J. Ramella-Roman +2 more
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Ethics of Preclinical Dopamine Transporter Imaging
Continuum, 2016While dopamine transporter single-photon emission computed tomography (DAT-SPECT) imaging is sensitive and specific when performed in patients with signs or symptoms of parkinsonism, its predictive value is uncertain in healthy subjects, even with patients who have first-degree relatives affected by Parkinson disease.
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Preclinical Imaging of siRNA Delivery
Australian Journal of Chemistry, 2016Small interfering RNA (siRNA) is emerging as a class of therapeutic with extremely high potential, particularly in the field of oncology. Despite this growing interest, further understanding of how siRNA behaves in vivo is still required before significant uptake into clinical application.
Fletcher, Nicholas +2 more
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Preclinical MRI Experience in Imaging Angiogenesis
Cancer and Metastasis Reviews, 2000Magnetic resonance imaging (MRI) provides a range of non-invasive measures for visualization of tumor angiogenesis in the clinic as well as in experimental tumor models. MRI methods were developed for assessment of spatial and temporal changes in perfusion, blood volume fraction, vascular permeability, vascular function, vascular maturation, vessel ...
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Challenges in Imaging in Preclinical Rheumatoid Arthritis
Rheumatic Disease Clinics of North America, 2014There exists a preclinical phase to the disease progression of rheumatoid arthritis, in which there is evidence of autoimmunity but no overt clinical arthritis. Identifying patients in this phase would allow for early treatment, to potentially halt manifestation of the disease.
Daniel P, Marcusa, Lisa A, Mandl
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Preclinical imaging in oncology: advances and perspectives
The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2017Preclinical imaging with radiolabeled probes became an integral part of the complex translational process that moves a newly developed compound from laboratory to clinical application. Imaging studies in animal tumor models may be undertaken to test a newly synthesized tracer, a newly developed drug or to interrogate, in the living organism, specific ...
Iommelli Francesca +3 more
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Imaging preclinical tumour models: improving translational power
Nature Reviews Cancer, 2014Recent developments and improvements of multimodal imaging methods for use in animal research have substantially strengthened the options of in vivo visualization of cancer-related processes over time. Moreover, technological developments in probe synthesis and labelling have resulted in imaging probes with the potential for basic research, as well as ...
de Jong +3 more
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