Results 251 to 260 of about 777,237 (284)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Preclinical Research on Cinnamic Acid Derivatives for the Prevention of Liver Damage: Promising Therapies for Liver Diseases. [PDF]

Biomedicines
Aldaba-Muruato LR, Escalante-Hipólito B, Alarcón-López AY, Martínez-Soriano PA, Angeles E, Macías-Pérez JR.   +5 more
europepmc   +1 more source

Application of Original Prostate Cancer Progression Model Interacting with Fibroblasts in Preclinical Research. [PDF]

J Clin Med
Ishii K, Iguchi K, Matsuda C, Hirokawa Y, Sugimura Y, Watanabe M.   +5 more
europepmc   +1 more source

Preclinical research (on rare diseases): we need to talk about health equity. [PDF]

Mamm Genome
Greenfield A.
europepmc   +1 more source

Considering Litter Effects in Preclinical Research: Evidence from E17.5 Acid-Sensing Ion Channel 2a Knockout Mice Exposed to Acute Seizures. [PDF]

Brain Sci
Warrington JP, Pryor T, Jones-Muhammad M, Shao Q.   +3 more
europepmc   +1 more source

FixThePig: a custom 3D-printed femoral intramedullary nailing for preclinical research applications. [PDF]

Front Bioeng Biotechnol
Manon J, Englebert A, Evrard R, Schubert T, Cornu O.   +4 more
europepmc   +1 more source

Unlocking New Therapeutic Options for Vincristine-Induced Neuropathic Pain: The Impact of Preclinical Research. [PDF]

Life (Basel)
Pușcașu C, Negreș S, Zbârcea CE, Chiriță C.   +3 more
europepmc   +1 more source

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Dogs in preclinical research

Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science), 2023
According to local and international regulatory documents, in addition to rodent second non-rodent species are required to provide sufficient toxicological data. The most commonly the Beagle dog is used as the second non-rodent species. The wide use of Beagle dogs has become possible due to a number of advantages of this breed: medium size, balanced ...
M.N. Makarova, V.G. Makarov
openaire   +1 more source

Rabbits in preclinical research

Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science), 2023
Rabbits are one of the most commonly used laboratory animal species in biomedical research. A large number of models of various human diseases have been developed on rabbits. Rabbits are widely used to assess the safety of substances and pharmaceuticals.
M.N. Makarova, V.G. Makarov
openaire   +1 more source