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Experimental models for preclinical cancer research
Experimental Cell Research, 2023The devastating disease of human cancers is a global health concern. In the past, development of effective therapies has been hindered by a shortage of reliable models; but in recent years, experimental models of human cancer for research are becoming more sophisticated.
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Hamster in preclinical research
Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)Members of the family Cricetidae in the order Rodentia are characterized by large cheek pouches that are used to transport and store food. In biomedical research the hamster is the third most frequently used laboratory animal following the rat and mouse.
M.N. Makarova, V.G. Makarov
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Preclinical Animal Models in Trauma Research
Journal of Orthopaedic Trauma, 2011Preclinical modeling of human disease with animals has not been standardized for many common pathologic processes. Assorted animal models are being used to investigate the pathogenesis, prevention, and treatment of disease processes. Certainly it is difficult to interpret the current literature because there are diverse and often irrelevant models ...
Edward J, Harvey +6 more
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False positive results in preclinical research
Therapies, 2017Therapie - Sous presse. Epreuves corrigees par l'auteur.
Denis, Angoulvant +1 more
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[Preclinical research--toxicology].
Arzneimittel-Forschung, 1975The different steps of the toxicological testing of new drugs are shortly described. Furthermore it is discussed that only 60-70% of the drug induced adverse reactions in man can be predicted by the experimental methods being available at present.
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The Preclinical Research Process
1996The preclinical research process extends from early assessments of feasibility of pharmaceutical development to providing regulatory authorities and clinical trial units with information necessary for administering the product to human subjects. Chief concerns include safety, which is evaluated in well-defined preclinical toxicology programs, and ...
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Gerbils in preclinical research
Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)The Mongolian gerbil — Meriones unguiculatus — has been used in biomedical research recently compared to other rodents (mice, rats, guinea pigs). The gerbil is generally non-aggressive and is one of the easiest rodents to keep and handle. Relative resistance to natural infectious and adaptability to the environment have contributed to the expansion of ...
M.N. Makarova, V.G. Makarov
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Intermittent fasting in the prevention and treatment of cancer
Ca-A Cancer Journal for Clinicians, 2021Katherine Clifton +2 more
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