Results 91 to 100 of about 2,106,963 (290)

EFFECTS OF THE JANUARY 30, 2016, Mw=7.2 ZHUPANOVSKY EARTHQUAKE ON THE WATER LEVEL VARIATIONS IN WELLS YUZ-5 AND E-1 IN KAMCHATKA

Геодинамика и тектонофизика, 2017
This paper describes the water level variations in wells YuZ-5 and E-1 inKamchatkaduring the Zhu­panovsky earthquake that occurred on January 30, 2016 (Mw=7.2, Н=180 km). The distances from the Zhupanovsky earthquake epicenter to wells E-1 and YuZ-5 were
S. V. Boldina, G. N. Kopylova
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mitochondrial protein import [PDF]

, 1987
The precursor of F0-ATPase subunit 9 was bound to mitochondria in the absence of a mitochondrial membrane potential (delta psi). Binding was mediated by a protease-sensitive component on the mitochondrial surface.
Harmey, Matthew A., Müller, Harald K., Neupert, Walter, Pfanner, Nikolaus   +3 more
core  

Are solar cycles predictable?

, 2007
Various methods (or recipes) have been proposed to predict future solar activity levels - with mixed success. Among these, some precursor methods based upon quantities determined around or a few years before solar minimum have provided rather high ...
Balmaceda, Brandenburg, Bushby, Cameron, Choudhuri, Dikpati, Dikpati, Echer, Harvey, Harvey, Hathaway, Hathaway, Hathaway, Lantos, Lantos, Layden, Legrand, Li, Ohl, Schatten, Schatten, Schatten, Sello, Solanki, Svalgaard, Thompson, Waldmeier, Wilson   +27 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Drop spreading and drifting on a spatially heterogeneous film: capturing variability with asymptotics and emulation [PDF]

, 2018
A liquid drop spreading over a thin heterogeneous precursor film (such as an inhaled droplet on the mucus-lined wall of a lung airway) will experience perturbations in shape and location as its advancing contact line encounters regions of low or high ...
Coveney, Sam, Jensen, Oliver E., Xu, Feng   +2 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Preparation and Performance of the Cathode Precursor Ferric Phosphate for Li-ion Battery Facilitated by Impinging Stream

International Journal of Electrochemical Science, 2013
An improved impinging stream reactor (ISR) was developed to synthesize the cathode precursor ferric phosphate by performing the reaction between Fe(NO3)3∙9H2O and H3PO4 with aqueous ammonia as the precipitating agent.
Yang Xiao, Weihua Pu, Wenbo Wan, Yufang Cui   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Precursors of short gamma-ray bursts

, 2010
We carried out a systematic search of precursors on the sample of short GRBs observed by Swift. We found that ~8-10% of short GRBs display such early episode of emission. One burst (GRB 090510) shows two precursor events, the former ~13 s and the latter ~
Abadie, Ackermann, Belczynski, Belczynski, Blinnikov, Bloom, Burlon, De Pasquale, Dessart, E. Troja, Giuliani, Harding, Heyl, Lazzati, Lazzati, Lyutikov, Lyutikov, McBreen, Morsony, Mészáros, N. Gehrels, Nakamura, Norris, Paciesas, Paczynski, Page, Piro, Rosswog, Ruffert, Ruffini, S. Rosswog, Scargle, Thompson, Thompson, Troja, Umeda, Vanderspek, Wang, Waxman, Zhang, Zhang   +40 more
core   +1 more source