Results 141 to 150 of about 5,969,771 (290)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Spacial Predation in the UK Newspaper Industry [PDF]

This paper investigates the alleged predatory behaviour in the UK quality newspaper industry in the 1990s using a horizontal differentiation model and industry data.Two-Sided Markets; Predation ...
Behringer, Stefan
core  

The EMA Qualification Opinion for CYP Inhibition‐Mediated Drug–Drug Interaction Predictions: Implications for PBPK Credibility Assessment in the Era of ICH M15

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical pharmacology and pharmacometrics teams are now being encouraged to implement the ICH M15 framework in drug development to support model‐informed decisions in regulatory submissions. Although model performance is an important component of model evaluation, regulatory confidence also depends on the intended context of use (CoU) and the ...
Karen Rowland Yeo, Sibylle Neuhoff, Oliver Hatley, Iain Gardner, Céline Brochot, Frédéric Y. Bois, Masoud Jamei   +6 more
wiley   +1 more source

Corporate Social Responsibility and Corporate Tax Avoidance in Europe: Evidence From the Anti‐Tax Avoidance Directives

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between corporate social responsibility (CSR) and corporate tax avoidance (CTA) in the European Union, exploiting institutional variation arising from CSR disclosure regimes and the introduction of the Anti‐Tax Avoidance Directives (ATAD).
Alessandro Migliavacca
wiley   +1 more source

Does ESG Drive Performance or Does Performance Enable ESG? Evidence of Reverse Causality From Korean Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The Environmental, Social, and Governance (ESG)‐performance literature has grown substantially, yet a fundamental question remains underexplored: do ESG investments improve firm performance, or do high‐performing firms simply invest more in ESG? We empirically address this question using panel vector autoregression with Granger causality tests
Jiyeon Kim, Wooyoung Yang
wiley   +1 more source

Artificial Intelligence and Corporate Social Irresponsibility

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines whether and how firms' adoption of artificial intelligence (AI) is associated with corporate social irresponsibility (CSI). Ex ante, theories provide conflicting predictions regarding this association, making it an important empirical question.
Tobias Steindl
wiley   +1 more source

The Hidden Arithmetic of Climate Disclosure: How a Decade of CDP Climate Scores Masks a Large Within‐Firm Rise and an Equally Large Composition Drag

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Using the full population of letter‐graded organisations in the licensed CDP climate score files from 2016 to 2025 (37,450 firm‐years across 8959 firms), this study examines how CDP‐assessed climate disclosure quality evolves over time.
Alexander Ryota Keeley, Jun Xie, Hidemichi Fujii, Shunsuke Managi   +3 more
wiley   +1 more source

Does EU Taxonomy Alignment Reduce Corporate Emissions? Evidence From Nordic Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper investigates whether EU Taxonomy alignment is associated with lower corporate emissions, using 982 firm‐years from 358 Nordic firms (2022–2025). Extending targeted transparency theory, the study develops a signal‐quality framework under which a mandated classification is informative only if it satisfies signal relevance, signal ...
Ane C. H. Jensen
wiley   +1 more source

When Does ESG Misconduct Cost the CEO? Sustainability Orientation and Compensation Outcomes Across European Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study provides new evidence on when environmental, social, and governance (ESG) controversies are associated with adverse CEO compensation outcomes and whether these consequences depend on firms' prior ESG orientation. Using 9131 firm‐year observations from listed firms in 11 European countries over 2015–2023, we examine the associations ...
László Szívós, Katalin Pádár
wiley   +1 more source

The Institutionalization of REIT Sustainability Reporting: Cross‐Country Evidence From ESG Disclosure Regimes and Building Sustainability Policies

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the institutionalization and textual evolution of sustainability reporting among listed real estate investment trusts (REITs) in the United States, the United Kingdom, Australia, Singapore, and Japan between 2020 and 2025.
Seonghun Min
wiley   +1 more source