Results 91 to 100 of about 29,214 (236)
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua +10 more
core +2 more sources
Journal of Diabetes InvestigationIntroduction Hyperglycemia or diabetes mellitus (DM) is a well‐known risk factor for pancreatic cancer, but it is uncertain whether well‐controlled glycemic status can affect the pancreatic cancer incidence rate.
Dong‐Hoe Koo +3 more
doaj +1 more source
Public Health Nursing, EarlyView.ABSTRACT Objectives This study aimed to identify high‐risk factors for type 2 diabetes and develop a machine learning (ML)–based diabetes prediction model using nursing notes from home health care. Design Retrospective cohort study. Sample A total 7896 medical records from 1747 patients aged ≥ 20 years who received home health care at a university ...
Doyeon LIM +3 more
wiley +1 more source
VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model [PDF]
, 2016 Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one. VIP (vasoactive intestinal peptide) has embryotrofic, anti-inflammatory and tolerogenic effects.
Calo, Guillermina +7 more
core +1 more source
Chronic glucocorticoid-rich milieu and liver dysfunction [PDF]
, 2016 We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats.
Castro, María Cecilia +7 more
core +6 more sources
Frontiers in Endocrinology, 2019 Background: Pre-diabetes is a risk factor for full-blown diabetes; it presents opportunities to prevent the actual diseases. It is therefore essential to identify effective preventive strategies, and to clarify the direction of future research.Methods ...
Zhi Sheng +10 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari +7 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract In this study, we investigated whether a structured aerobic exercise programme could enhance microRNA‐126 (miR‐126) expression and improve subclinical atherosclerosis markers [carotid intima–media thickness (CIMT) and ankle–brachial index (ABI)] in individuals with prediabetes.
Elif Yildirim Ayaz +9 more
wiley +1 more source
Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
The Journal of Physiology, EarlyView.Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson +7 more
wiley +1 more source
Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role? [PDF]
, 2018 Secondary adrenal insufficiency (SAI) is a potentially life-threatening endocrine disorder due to an impairment of corticotropin (ACTH) secretion from any process affecting the hypothalamus or pituitary gland.
Gianfrilli, Daniele +5 more
core +2 more sources