Results 71 to 80 of about 3,894,585 (291)

Parental height in relation to offspring coronary heart disease: examining transgenerational influences on health using the west of Scotland Midspan Family Study [PDF]

, 2012
<b>Background </b>Adult height is known to be inversely related to coronary heart disease (CHD) risk. We sought to investigate transgenerational influence of parental height on offspring’s CHD risk.
Batty, G.D., Hart, Carole L., McConnachie, A., Gray, L., Watt, G.C., Smith, George Davey, McConnachie, Alex, Upton, M.N., Upton, Mark N., Davey Smith, G., Hart, C.L., Macfarlane, P.W., Gray, Linsay, Watt, Graham C. M., Batty, G. David, Macfarlane, Peter W.   +15 more
core   +1 more source

Disentangling the Genetic Relationship Between Sleep and Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A bidirectional relationship between sleep and epilepsy is well recognised, yet the biological mechanisms linking them remain poorly understood. Both have a genetic basis, with genome‐wide association studies (GWAS) capturing polygenic contributions.
Khang N. Le, Victoria E. Jackson, Rachel E. Stirling, Zachary F. Gerring, Remi Stevelink, Samuel F. Berkovic, Ingrid E. Scheffer, Philippa J. Karoly, Melanie Bahlo, Karen L. Oliver   +9 more
wiley   +1 more source

Quantifying the impact of early life growth adversity on later life health

Communications Medicine
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would associate with ...
Raphael Goldman-Pham, Matthew P. Alter, Rebecca Bao, Sophie É. Collins, Catherine L. Debban, James P. Allinson, Antony Ambler, Alain G. Bertoni, Avshalom Caspi, Stephanie Lovinsky-Desir, Magnus P. Ekstrom, James C. Engert, David R. Jacobs, Daniel Malinsky, Ani Manichaikul, Erin D. Michos, Terrie E. Moffitt, Elizabeth C. Oelsner, Sandhya Ramrakha, Stephen S. Rich, Coralynn Sack, Sanja Stanojevic, Padmaja Subbarao, Karen Sugden, Reremoana Theodore, Karol E. Watson, Benjamin Williams, Bin Yang, Josée Dupuis, Seif O. Shaheen, R. Graham Barr, Robert J. Hancox, Benjamin M. Smith   +32 more
doaj   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Beyond growth velocity: a dual-criterion framework for selective recombinant human growth hormone combination therapy in girls with idiopathic central precocious puberty

Frontiers in Endocrinology
Gonadotropin-releasing hormone analog (GnRHa) serves as the first-line therapy for girls with idiopathic central precocious puberty (ICPP). Treatment-related growth deceleration is a predictable pharmacological consequence of GnRHa administration ...
Wei Liu
doaj   +1 more source

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

Criteria for First-Year Growth Response to Growth Hormone Treatment in Prepubertal Children With Growth Hormone Deficiency: Do They Predict Poor Adult Height Outcome?

Frontiers in Endocrinology, 2019
Objective: Several criteria for first-year growth response (FYGR) to growth hormone (GH) treatment have been proposed. We explored which FYGR criteria predicted best the final height outcome after GH treatment in prepubertal children with GH deficiency ...
Saartje Straetemans, Saartje Straetemans, Saartje Straetemans, Jean De Schepper, Jean De Schepper, Jean De Schepper, Muriel Thomas, Sylvie Tenoutasse, Sylvie Tenoutasse, Véronique Beauloye, Véronique Beauloye, Raoul Rooman, Raoul Rooman   +12 more
doaj   +1 more source

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE).
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source