Results 111 to 120 of about 2,112,128 (293)

Predictive coding in psychopathology: mechanistic model or metaphorical re-description?

Frontiers in Human Neuroscience
Predictive coding (PC) has become a central framework in contemporary cognitive neuroscience, proposing that the brain operates as a hierarchical inference system that continuously minimizes the mismatch between predicted and actual sensory input.
Albandri Sultan Alotaibi
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Variational free energy as a conceptual framework for understanding habituation in spinal cord stimulation

Frontiers in Pain Research
IntroductionHabituation, or loss of clinical benefit over time, is a frequent problem in spinal cord stimulation (SCS). Existing programming strategies such as waveform cycling or closed-loop stimulation try to address it, but there is no common ...
Alexander Taghva, Alexander Taghva
doaj   +1 more source

Predicting Errors in Concurrent Systems

, 2017
Die Verbreitung von Multikernprozessoren hat die parallele Programmierung allgegenwärtig gemacht. Parallele Programmierung ist schwierig, da sie die Entwicklung auf Grund vielfacher Kontrollflüsse und Nicht-Determinismus fehleranfällig macht. Zusätzlich gibt es neue Arten von Fehlern, wie z.B. Wettläufe, Verklemmungen oder Reihenfolgeverletzung.
openaire   +4 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A semi-mechanistic modeling strategy for infectious diseases forecasting: Error correction and probabilistic prediction

Biosafety and Health
Global climate change and technological advancements have intensified the threats of pandemics, while complex transmission dynamics challenge infectious disease forecasting.
Zihan Hao, Jiaxuan Hu, Shujuan Hu, Zhen Zhang, Donghuai Jia, Jianping Huang   +5 more
doaj   +1 more source

Wait for it: Predicted Error vs. Prediction Error in Language Processing

, 2016
Poster presented at 2015 meeting of the Society for the Neurobiology of ...
Alday, Phillip M., Sassenhagen, Jona, Coussens, Scott, Bornkessel-Schlesewsky, Ina   +3 more
openaire   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Error in Enumerable Sequence Prediction

, 2006
We outline a method for quantifying the error of a sequence prediction. With sequence predictions represented by semimeasures $ u(x)$ we define their error to be $-log_2 u(x)$. We note that enumerable semimeasures are those which model the sequence as the output of a computable system given unknown input.
openaire   +4 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source