Results 141 to 150 of about 6,561,703 (356)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Modulation of sensory prediction error in Purkinje cells during visual feedback manipulations

Nature Communications, 2018
It is hypothesized that the cerebellum implements a forward internal model that transforms motor commands into predictions about upcoming movements. The predictions are compared with sensory feedback to generate sensory prediction errors critical to ...
M. L. Streng, Laurentiu S. Popa, T. Ebner   +2 more
semanticscholar   +1 more source

To update or to separate: Neural signatures and consequences of latent cause inference in episodic memory

NeuroImage
Episodic memories are leveraged to predict upcoming input. Latent Cause Theory (Gershman et al., 2017) predicts that after moderate prediction errors, existing memories will be updated by integrating new information, while after large prediction errors ...
Marius Boeltzig, Sophie Siestrup, Inês Bramão, Ricarda I. Schubotz   +3 more
doaj   +1 more source

The Implementation of Predictions During Sequencing

Frontiers in Cellular Neuroscience, 2019
Optimal control mechanisms require prediction capabilities. If one cannot predict the consequences of a motor act or behavior, one will continually collide with walls or become a social pariah.
M. Molinari, M. Masciullo
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Predictive coding in psychopathology: mechanistic model or metaphorical re-description?

Frontiers in Human Neuroscience
Predictive coding (PC) has become a central framework in contemporary cognitive neuroscience, proposing that the brain operates as a hierarchical inference system that continuously minimizes the mismatch between predicted and actual sensory input.
Albandri Sultan Alotaibi
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Artificial neural network algorithm for online glucose prediction from continuous glucose monitoring.

, 2010
Background and Aims: Continuous glucose monitoring (CGM) devices could be useful for real-time management of diabetes therapy. In particular, CGM information could be used in real time to predict future glucose levels in order to prevent hypo ...
Pérez Gandía, Carmen, DE LEIVA A, Hernando Pérez, María Elena, Gómez Aguilera, Enrique J., SPARACINO, GIOVANNI, Rigla Cros, Mercedes, RIGLA M, GOMEZ EJ, HERNANDO ME, Leiva, Alberto de, Sparacino, G., PEREZ GANDIA C, COBELLI, CLAUDIO, Facchinetti, A., Cobelli, C., FACCHINETTI, ANDREA   +15 more
core   +2 more sources

Variational free energy as a conceptual framework for understanding habituation in spinal cord stimulation

Frontiers in Pain Research
IntroductionHabituation, or loss of clinical benefit over time, is a frequent problem in spinal cord stimulation (SCS). Existing programming strategies such as waveform cycling or closed-loop stimulation try to address it, but there is no common ...
Alexander Taghva, Alexander Taghva
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source