Results 101 to 110 of about 563,114 (266)

Human cerebellum and ventral tegmental area interact during extinction of learned fear

eLife
The key elements for fear extinction learning are unexpected omissions of expected aversive events, which are considered to be rewarding. Given its reception of reward information, we tested the hypothesis that the cerebellum contributes to reward-like ...
Enzo Nio, Patrick Pais Pereira, Nicolas Diekmann, Mykola Petrenko, Alice Doubliez, Thomas Michael Ernst, Giorgi Batsikadze, Stefan Maderwald, Cornelius Deuschl, Metin Üngör, Sen Cheng, Christian Josef Merz, Harald H Quick, Dagmar Timmann   +13 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Predictability of Mandibular Autorotation After Maxillary Repositioning in Orthognathic Surgery: A Systematic Review with Exploratory Quantitative Synthesis

Applied Sciences
This systematic review aimed to evaluate the available evidence on methods used to predict mandibular autorotation after maxillary repositioning in orthognathic surgery. A systematic search of PubMed/MEDLINE, Cochrane Library, Scopus, Google Scholar, and
Andrii Hresko, Veronica Scocca, Josefina Santana, Gwen R. J. Swennen   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Predicting Errors in Concurrent Systems

, 2017
Die Verbreitung von Multikernprozessoren hat die parallele Programmierung allgegenwärtig gemacht. Parallele Programmierung ist schwierig, da sie die Entwicklung auf Grund vielfacher Kontrollflüsse und Nicht-Determinismus fehleranfällig macht. Zusätzlich gibt es neue Arten von Fehlern, wie z.B. Wettläufe, Verklemmungen oder Reihenfolgeverletzung.
openaire   +4 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Error in Enumerable Sequence Prediction

, 2006
We outline a method for quantifying the error of a sequence prediction. With sequence predictions represented by semimeasures $ u(x)$ we define their error to be $-log_2 u(x)$. We note that enumerable semimeasures are those which model the sequence as the output of a computable system given unknown input.
openaire   +4 more sources

Coupling a firefly algorithm with support vector regression to predict evaporation in northern Iran

Engineering Applications of Computational Fluid Mechanics, 2018
Evaporation accounts for varying shares of water balance under different climatic conditions, and its correct prediction poses a significant challenge before water resources management in watersheds.
Roozbeh Moazenzadeh, Babak Mohammadi, Shahaboddin Shamshirband, Kwok-wing Chau   +3 more
doaj   +1 more source