Results 121 to 130 of about 1,720,597 (315)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Locally induced predictive models
2011 IEEE International Conference on Systems, Man, and Cybernetics, 2011 Most predictive modeling techniques utilize all available data to build global models. This is despite the wellknown fact that for many problems, the targeted relationship varies greatly over the input space, thus suggesting that localized models may improve predictive performance.
Ulf Johansson +2 more
openaire +4 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Bootstrap prediction mean squared errors of unobserved states based on the Kalman filter with estimated parameters [PDF]
, 2010 Prediction intervals in State Space models can be obtained by assuming Gaussian innovations and using the prediction equations of the Kalman filter, where the true parameters are substituted by consistent estimates.
Ruiz Ortega, Esther +2 more
core
Comparative Analysis of Object-Oriented Software Maintainability Prediction Models
Foundations of Computing and Decision Sciences, 2018 Software maintainability is one of the most important aspects when evaluating the quality of a software product. It is defined as the ease with which the existing software can be modified.
Zighed Narimane +2 more
doaj +1 more source
Models for Understanding Versus Models for Prediction [PDF]
, 2008 According to a standard point of view, statistical modelling consists in establishing a parsimonious representation of a random phenomenon, generally based upon the knowledge of an expert of the application field: the aim of a model is to provide a better understanding of data and of the underlying mechanism which have produced it.
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Sensitivity Analysis for a Scenario-Based Reliability Prediction Model [PDF]
, 2005 As a popular means for capturing behavioural requirements, scenariosshow how components interact to provide system-level functionality.If component reliability information is available, scenarioscan be used to perform early system reliability assessment.
David S. Rosenblum +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source