Results 91 to 100 of about 8,729,244 (299)
Editorial for the special issue: “Novel solutions or novel approaches in Operational Research”
Business Systems Research, 2016 The special issue of Business Systems Research (SI of BSR) is co-published by the Slovenian Society INFORMATIKA – Section for Operational Research (SSI – SOR) and contains developments and new techniques in operations research (OR) models and their ...
Dumičić Ksenija +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Safety Performance Functions for Low-Volume Roads
The Baltic Journal of Road and Bridge Engineering, 2011 This paper analyzes roadway safety conditions using the network approach for a number of Italian roadways within the Province of Salerno. These roadways are characterized by low-volume conditions with a traffic flow of under 1000 vpd and they are ...
Gianluca Dell’Acqua, Francesca Russo
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Validation of death prediction after breast cancer relapses using joint models. [PDF]
, 2015 BACKGROUND: Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent event and a terminal event to derive
Sabine Siesling +16 more
core +3 more sources
Materiales de Construccion, 2009 Service life definitions involve more considerations today than thirty years ago. This is because only mechanical parameters were taken into account by then.
J. M. Mendoza-Rangel, P. Castro-Borges
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Advances in Neural Information Processing Systems 37Accepted to NeurIPS ...
Ramy Mounir, Sudeep Sarkar
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source