Results 241 to 250 of about 8,729,244 (299)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Prediction models in prostate cancer: a systematic review and meta-analysis. [PDF]

Front Oncol
Israel EN, Niels KN, Makanjuola OO, Rotimi OA, Afolabi IS.   +4 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Risk prediction models for inadequate bowel preparation before colonoscopy: A systematic review and meta-analysis. [PDF]

PLoS One
Yan HL, Fu JY, Huang MT, Yi WT, Liu JJ, Huang XY, Fang Y, Zhao L, Chen YS, Zeng Y.   +9 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Prediction models for postoperative recurrence in papillary thyroid carcinoma: a systematic review and critical appraisal. [PDF]

Front Endocrinol (Lausanne)
Yang Y, Wang P, Zhou L, Diao R, Guo C.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Prediction models for prolonged air leak after pulmonary surgery: a systematic review and critical appraisal. [PDF]

Front Oncol
Du N, Zhang M, Wang X, Zhang L, Zhou Y, Song C.   +5 more
europepmc   +1 more source

Amyloidosis secondary to familial Mediterranean fever: machine learning-based prediction models. [PDF]

Rheumatology (Oxford)
Aktas B, Azman E, Oner YE, Kaya K, Yuksel HM, Hosgel A, Karahan KD, Coban ZB, Parlar K, Kilinc OC, Acar B, Ugurlu S.   +11 more
europepmc   +1 more source

Critical Artifacts Improve Reproducibility of Protein-Ligand Binding Affinity Prediction Models on CASF-2016. [PDF]

J Chem Inf Model
Eaves JN, Needs AA, Woldring DR.
europepmc   +1 more source