Results 161 to 170 of about 60,929 (294)

Linking atrial fibrillation to cerebral small vessel disease: a cross-sectional study with predictive analytics. [PDF]

Front Cardiovasc Med
Shang J, Fan L, Xu J, Sui X.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

SAFEGUARD: Transforming Military Suicide Prevention Through Predictive Analytics and Targeted Interventions. [PDF]

Curr Psychiatry Rep
Nassif TH, Adler AB, Atkinson RD, Bentley KH, Bonomi RE, D'Olympia J, Edwards ER, Fortgang RG, Gaudiano BA, Geraci JC, Goodman M, Herman D, Kleiman EM, Maggio S, McDaniel A, Naifeh JA, Nock MK, Paine C, Regan T, Torous J, Capaldi VF, Kessler RC.   +21 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Predictive analytics in aviation management

The aviation industry has undergone significant changes driven by technological advancements and changing consumer demands (Joseph 2023). One area that has seen notable growth is Predictive Analytics (PA), which involves using historical information to ...
Wang, Yi, Rampersad-Jagmohan, Melissa
core   +1 more source

Ethical challenges and opportunities for integrating predictive analytics in community-based overdose prevention. [PDF]

Lancet Reg Health Am
Allen B, Urmanche A, Curtis B, Fisher C.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Enhancing healthcare outcome with scalable processing and predictive analytics via cloud healthcare API. [PDF]

Front Digit Health
Salehi SS, Saadatfar H, Oyelere SS, Hussain S, Hassannataj Joloudari J, Taheri Ledari M, Arslan E, Barzegar B.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Predictive analytics to direct clinical attention to complex patients with elevated suicide risk: enhancement of the Veterans Health Administration REACH VET model. [PDF]

BMJ Ment Health
Peluso A, Ramirez Osorio J, Kazanis WH, Robinson A, Martins SB, Cook H, Callaway K, Schaefferkoetter N, McCarthy JF, Oliva EM, Kapadia A, Trafton JA.   +11 more
europepmc   +1 more source