Results 141 to 150 of about 2,210,189 (286)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
THEORETICAL FRAMEWORKS OF ECOPFM PREDICTIVE MAINTENANCE (ECOPFM) PREDICTIVE MAINTENANCE SYSTEM
Engineering Science & Technology JournalThe Frameworks of EcoPFM Predictive Maintenance (PM) System presents a novel approach to maintenance optimization within eco-friendly power facilities, addressing the critical need for sustainable, efficient asset management. This paper introduces an integrated framework leveraging advanced predictive analytics, machine learning algorithms, and ...
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Vanilla LSTM Predictive Maintenance Model for Scientific Research Facilities. [PDF]
Sensors (Basel)Nkadimeng E +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
A Multimodal TinyML-Based Predictive Maintenance Architecture for Industrial IoT in the 6G Era. [PDF]
Sensors (Basel)Garay CE +7 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Benchmark datasets for predictive maintenance challenges in steel manufacturing. [PDF]
Front Artif IntellJakubowski J, Bobek S, Nalepa GJ.
europepmc +1 more source
A high level e-maintenance architecture to support on-site teams [PDF]
Emergent architectures and paradigms targeting reconfigurable manufacturing systems increasingly rely on intelligent modules to maximize the robustness and responsiveness of modern installations. Although intelligent behaviour significantly minimizes the
José Barata +2 more
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