Results 101 to 110 of about 4,279,934 (276)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Frontiers in MicrobiologyMicrobial contamination of water sources is a pressing global challenge, disproportionately affecting developing regions with inadequate infrastructure and limited access to safe drinking water. In the Global South, waterborne pathogens such as bacteria,
Sylvester Chibueze Izah +1 more
doaj +1 more source
A model of bankruptcy prediction
, 2001 By this thesis Eivind Bernhardsen completed his cand.oecon. degree at the University of Oslo. The thesis was financed by Norges Bank and was written as a part of a project on the development of supervisory credit risk models.
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Models for Understanding Versus Models for Prediction [PDF]
, 2008 According to a standard point of view, statistical modelling consists in establishing a parsimonious representation of a random phenomenon, generally based upon the knowledge of an expert of the application field: the aim of a model is to provide a better understanding of data and of the underlying mechanism which have produced it.
openaire +3 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
IEEE AccessPresents corrections to the paper, (Predictive Analytics for Mortality: FSRNCA-FLANN Modeling Using Public Health Inventory Records).
Manish Kumar +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Elementary operations on Gaussian fuzzy numbers for predictive modeling
Complex & Intelligent SystemsElementary operations with fuzzy numbers are essential for implementing predictive fuzzy modeling. Although operations with triangular fuzzy numbers are well-established, they are not adequately studied for predictive modeling with Gaussian fuzzy numbers,
Georgios Charizanos +2 more
doaj +1 more source