Results 91 to 100 of about 161,608 (297)
Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients
British Journal of Clinical Pharmacology, EarlyView.Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen +14 more
wiley +1 more source
, 1991 To assess the bioavailability of a oral prednisolone preparation, prednisolone crossover pharmacokinetics were studied in eight healthy male volunteers following intravenous infusion of prednisolone sodium phosphate 81 mg (equivalent to prednisolone ...
Lee, Kyeong-Hun
core
Lost and found in translation: the value of the human imiquimod model
British Journal of Clinical Pharmacology, EarlyView.Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs +6 more
wiley +1 more source
Alternative treatment regimens in autoimmune hepatitis: how justified is their choice?
Alʹmanah Kliničeskoj Mediciny, 2018 Autoimmune hepatitis is a progressive immune-mediated liver disease of unknown etiology. Its key characteristics include hyper-gammaglobulinemia, circulating autoantibodies, and periportal inflammation seen in a liver biopsy sample.
M. V. Matsievich +2 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari +6 more
wiley +1 more source
New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells
Frontiers in Immunology, 2017 Memory T-cells, particularly, effector memory T cells are implicated in the pathogenesis of inflammatory diseases and may contribute to tissue injury and disease progression.
Edessa Negera +8 more
doaj +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Naringenin modifies T-helper responses and macrophage activities in BALB/c mice [PDF]
Avicenna Journal of PhytomedicineObjective: Naringenin is a naturally occurring flavonoid found in citrus fruits. This study was done to compare the oral immunomodulatory effects of naringenin and prednisolone.
Fatemeh Keivan +1 more
doaj +1 more source
, 2014 How to Cite This Article: Khajeh A, Fayyazi A, Soleimani Gh, Miri-Aliabad Gh, Shaykh Veisi S, Khajeh B. Comparison of the Efficacy ofCombination Therapy of Prednisolone-Acyclovir with Prednisolone Alone in Bell’s Palsy. Iran J Child Neurol.
KHAJEH, Ali +5 more
core +1 more source
BMEMat, EarlyView.Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu +7 more
wiley +1 more source