Results 111 to 120 of about 13,683 (282)
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
A Dynamic Duopoly Investment Game without Commitment under Uncertain Market Expansion [PDF]
We model capacity-building investments in a homogeneous product duopoly facing uncertain demand growth. Capacity building is achieved through the addition of production units that are durable and lumpy and whose cost is irreversible. While building their
Pierre Lasserre +2 more
core
Revisiting the Sources of Parental Knowledge and Tracking Their Between‐ and Within‐Person Dynamics
Journal of Adolescence, EarlyView.ABSTRACT Introduction In their seminal work, Stattin and Kerr (2000) identified three sources of parental knowledge: child disclosure, parental solicitation, and parental control. While this conceptualization has led to significant theoretical and practical contributions, the boundaries among the three sources are not always clear. In the current study,
Natali Goueta +2 more
wiley +1 more source
Technology diffusion in a differentiated industry [PDF]
, 1994 This paper investigates the adoption timing pattern of a cost-reducing innovation in a differentiated oligopolistic industry. It compares price and quantity market competition with the second-best optimal adoption rule.
Petrakis, Emmanuel
core +1 more source
Federal preemption issues in banking
, 2010 Title from Web page (OLR web site, viewed Feb. 17, 2010).; "February 1, 2010."; Discusses federal preemption issues in banking. Discusses the areas in which the state can still legislate and where federal law preempts state law.
Hayes, Jeanne.
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Journal of Counseling &Development, EarlyView.ABSTRACT This interpretative phenomenological study examined the lived experiences of nonreligious and nonspiritual (NRNS) individuals seeking counseling while living in the Bible Belt of the United States. Semistructured interviews were conducted with adults who self‐identified as NRNS and resided in the Bible Belt of the United States.
Travis McKie‐Voerste
wiley +1 more source
IET Intelligent Transport SystemsIn urban areas, emergency vehicles (EVs) need efficient traffic signal preemption to ensure timely responses during peak hours. While emergency vehicle traffic signal preemption (EVTSP) has garnered significant attention in the literature, the issues of ...
Yen‐Yu Chen +3 more
doaj +1 more source
A Dynamic Duopoly Investment Game under Uncertain Market Growth [PDF]
We model investments in capacity in a homogeneous product duopoly facing uncertain demand growth. Capacity building is achieved through adding production units that are durable and lumpy and whose cost is irreversible.
Moreaux, Michel +2 more
core
The preemptive resource-constrained project scheduling problem subject to due dates and preemption penalties: An integer programming approach [PDF]
Journal of Optimization in Industrial Engineering, 2010 Extensive research has been devoted to resource constrained project scheduling problem. However, little attention has been paid to problems where a certain time penalty must be incurred if activity preemption is allowed.
Behrouz Afshar nadjafi, Shahram Shadrokh
doaj