Results 71 to 80 of about 1,036,256 (255)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu   +12 more
wiley   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

open access: yesAdvanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli   +16 more
wiley   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

open access: yesAdvanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan   +11 more
wiley   +1 more source

Preface, Organisation, and Table of Content

open access: yesInformation Research: An International Electronic Journal
CoLIS is a series of international conferences aiming to provide a broad forum for the exploration and exchange of ideas in the field of Library and Information Science, Information Studies, and related disciplines.
Perla Innocenti, Emma Nicol, Ian Ruthven
doaj   +1 more source

The Translation Process: The Status of Tranface (the Translator’s Preface) Among Iranian Readers

open access: yesInternational Journal of Language and Translation Studies, 2022
Tranface is a valuable resource for the readers that contains useful information about the translator and translation. It also enables the translator to become more visible and promote his/her status in the society.
Hamidreza Abdi
doaj  

Review of: The Ethics of Reproductive Technology (Kenneth D. Alpern ed., Oxford University Press 1992) [PDF]

open access: yes, 1994
Review of: The Ethics of Reproductive Technology (Kenneth D. Alpern ed., Oxford University Press 1992). Additional readings, glossary, introduction, notes, preface. LC 92-8252; ISBN 0-19-507435-1. [370 pp. Paper $19.95.
Ferber, Rochelle S.
core   +2 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

PREFACE ANALYSIS IN PRE-STANDARD CROATIAN GRAMMARS [PDF]

open access: yesHum, 2018
The endeavour of this paper is to describe and show the content and function of the preface text in Croatian printed pre-standard grammars from the 17th century until the first half of the 19th century, actually until the appearance of the Croatian ...
Vesna Grahovac-Pražić
doaj  

Review of: Dorothy J. Howell, Ecology for Environmental Professionals (Quorum Books 1994) [PDF]

open access: yes, 1995
Review of: Dorothy J. Howell, Ecology for Environmental Professionals (Quorum Books 1994). Appendices, bibliographical references, figures, glossary, index, preface, tables. LC 93-5580; ISBN 0-89930-745-0 [215 pp. Cloth $59.95.
McManus, Karla Sievers
core   +2 more sources

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