A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova +5 more
wiley +1 more source
Patient preferences for pancreatic cancer treatment (PERSEUS): a multicenter discrete choice experiment. [PDF]
Lansbergen MF +18 more
europepmc +1 more source
Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer +10 more
wiley +1 more source
Urban-Rural Differences in Preferences for Environmentally Friendly Farming from the Perspectives of Oriental White Stork Conservation. [PDF]
Zhang L +5 more
europepmc +1 more source
A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra +8 more
wiley +1 more source
A structure-guided approach to noncoding variant evaluation for transcription factor binding using AlphaFold 3. [PDF]
Gerasimavicius L, Biddie SC, Marsh JA.
europepmc +1 more source
Flexible Polypyrrole‐Based pH Sensors via Oxidative Chemical Vapor Deposition
Oxidative chemical vapor deposition (oCVD) of polypyrrole (PPy) thin films yields flexible, electrically conductive, and biocompatible pH sensors for monitoring on‐skin biological events. The highly sensitive, oCVD PPy skin‐conformal sensors enable real‐time, spatially resolved sensing of dynamic pH changes within physiologically relevant ranges (4–9 ...
Adrivit Mukherjee +15 more
wiley +1 more source
Using a discrete choice experiments to explore societal preferences for valuing new drugs for rare diseases. [PDF]
Vargas C +4 more
europepmc +1 more source

