Results 61 to 70 of about 394,905 (308)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in Psychology, 2022 This study uses a discrete choice experiment to examine consumers’ preferences for Fuji apple product attributes and willingness to pay (WTP) estimates for consumers in six cities in China.
Ruifeng Liu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
VaccinesObjectives: Hepatitis E virus (HEV) infection is associated with severe hepatitis and high mortality rates, yet vaccination coverage remains suboptimal.
Yuanqiong Chen +8 more
doaj +1 more source
Son preference and health disparities in developing countries
SSM: Population Health, 2022 Recorded history demonstrates the preference for sons in every aspect of life. Today, despite being considered a powerful manifestation of gender inequality and discrimination against women, the preference for sons over daughters is still prevalent ...
Kien Le, My Nguyen
doaj +1 more source
Partial Identification in Matching Models for the Marriage Market
, 2020 We study partial identification of the preference parameters in models of one-to-one matching with perfectly transferable utilities, without imposing parametric distributional restrictions on the unobserved heterogeneity and with data on one large market.
Gualdani, Cristina, Sinha, Shruti
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
How Important Is Discount Rate Heterogeneity for Wealth Inequality? [PDF]
This paper investigates the role of discount rate heterogeneity for wealth inequality. The key idea is to infer the distribution of preference parameters from the observed age profile of wealth inequality.
Lutz Hendricks
core +3 more sources
Vaccines, 2022 (1) Background: Since China’s national vaccination policy announcement in January 2021, individual vaccination preferences related to vaccine characteristics, social relationships, sociodemographic characteristics and cognition remain opaque.
Siyuan Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source