Results 121 to 130 of about 35,645 (304)

Robust and Thermally Stable Silicone Aerogels with Hyperconnected Network via Kinetically Optimized Hyperbranched Silane Precursors

Advanced Science, EarlyView.
Reactivity‐Programmed Assembly: A kinetic‐control strategy is reported for constructing hyperconnected silicone aerogels with a robust “thick‐neck” architecture. By exploiting the reactivity disparity of precursors, flexible segments are uniformly embedded within a rigid skeleton.
Aoqing Yan, Guixiang Li, Yaolan Li, Yi Luo, Bin Liu, Zhe Su, Hao Tian, Wei Shi, Bo Niu, Donghui Long   +9 more
wiley   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Physics-Informed Preform Design for Flashless 3D Forging via Material Point Backtracking and Finite Element Simulations

Journal of Manufacturing and Materials Processing
Accurate preform design in forging processes is critical for improving part quality, conserving material, reducing manufacturing costs, and eliminating secondary operations.
Gracious Ngaile, Karthikeyan Kumaran
doaj   +1 more source

Role of Surface Texture on Workpiece Angular Deformation in Cross Wedge Rolling [PDF]

, 2011
The cross wedge rolling process is commonly used for the manufacturing of shaft or for preforms, being used for preliminary operation of forming cycle.
BIGOT, Régis, LANGLOIS, Laurent, MANGIN, Philippe   +2 more
core   +3 more sources

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Surface Morphology Prediction of Preforms in Rotational Braiding Process Based on Yarn Interlacement

Nanjing Hangkong Hangtian Daxue Xuebao
Rotary braiding is an efficient composite preform molding process， and the design of process parameters during braiding is crucial to the preform’s forming quality.
ZHU Xiangyu, SHAN Zhongde, SUN Zheng, GUO Zitong, WANG Yaoyao, LIU Jiale¹, GAO Yicen¹, SUN Xianpeng³   +7 more
doaj   +1 more source

Mullite Whiskers and Mullite-whisker Felt [PDF]

, 1993
The Naval Surface Warfare Center has developed processes for the preparation of mullite (3(Al2O3)(dot)2(SiO2)) whiskers and mullite-whisker felt. Three patents on the technology were issued in 1990.
Haught, Deborah A., Talmy, Inna G.
core   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Integral throat entrance development, qualification and production for the Antares 3 nozzle [PDF]

Although design analyses of a G-90 graphite integral throat entrance for the Antares 3 solid rocket motor nozzle indicated acceptable margins of safety, the nozzle throat insert suffered a thermostructural failure during the first development firing ...
Clayton, F. I., Dirling, R. B., Eitman, D. A., Loomis, W. C.   +3 more
core   +1 more source

FE modelling of a structurally stitched multilayer composite [PDF]

, 2010
Finite-element models are presented for a typical structurally stitched carbonfibre composite. The term 'structural' means that the stitching yarn is thick enough to form a through-the-thickness reinforcement.
Klimshin, D.V., Koissin, V, Lomov, S.V., Verpoest, I.   +3 more
core   +1 more source