Results 181 to 190 of about 301,999 (239)

Routine 36-week scan: prediction of prolonged neonatal intensive care unit admission. [PDF]

open access: yesUltrasound Obstet Gynecol
Arechvo A   +7 more
europepmc   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

open access: yesAdvanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li   +32 more
wiley   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

open access: yesAdvanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu   +15 more
wiley   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

open access: yesAdvanced Science, EarlyView.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou   +15 more
wiley   +1 more source

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

open access: yesAdvanced Science, EarlyView.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang   +13 more
wiley   +1 more source

Adverse pregnancy outcomes and associated factors among mothers who had operative vaginal delivery in Amhara Region Comprehensive Specialized Hospitals: multicentre cross-sectional study. [PDF]

open access: yesBMJ Open
Misker AD   +17 more
europepmc   +1 more source

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

open access: yesAdvanced Science, EarlyView.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang   +14 more
wiley   +1 more source

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