Results 241 to 250 of about 1,959,827 (318)

Pregnancy and Childbirth in Neurodivergent Women: Shift Towards Personalized Maternity Care. [PDF]

J Pers Med
Avdeeva AM, Parfenenko MA, Bryzgalina EV, Muminova KT, Khodzhaeva ZS.   +4 more
europepmc   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Fetal Bradycardia Prompting the Diagnosis and Management of Parental Long QT Syndrome. [PDF]

Circ Arrhythm Electrophysiol
Ananthan K, Chivers S, Regan W, de Marvao A, Vigneswaran T, Rosenthal E, Zidere V, Homfray T, Williamson C, Simpson JM, Bastiaenen R, Whitaker J.   +11 more
europepmc   +1 more source

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Association between induction of labor and birth experience: A national population-based study. [PDF]

Acta Obstet Gynecol Scand
Braund S, Goffinet F, Girault A, Seco A, Le Ray C, ENP2021 study group.   +5 more
europepmc   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

The migration of placenta even after 30 gestational weeks is a risk factor for postpartum hemorrhage. [PDF]

AJOG Glob Rep
Yamamoto G, Hiramatsu K, Kawanishi Y, Kakuda M, Nakamura K, Miyake T, Mimura K, Kimura T, Endo M, Kimura T, Kodama M.   +10 more
europepmc   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Pain and anesthesia - on fetal nervous system and brain development. [PDF]

Front Pharmacol
Gao M, Bao G, Bai S.
europepmc   +1 more source

Sex Offenses: An Anthropological Perspective [PDF]

, 1960
Ford, Clellan S.
core   +1 more source