Results 21 to 30 of about 23,283 (253)

Case report of ectopic pregnancy occurring in the tubal stump after a previous salpingectomy

Nigerian Journal of Medicine, 2023
Tubal stump ectopic pregnancy is rare but a potentially life-threatening condition. A high index of suspicion is required for early diagnosis and effective treatment, thereby minimising morbidity associated with this type of abnormal pregnancy.
Maradona E Isikhuemen, Weyinmi E Kubeyinje   +1 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Development and validation of a predictive nomogram for the pregnancy rate after tubal anastomosis in women with tubal ligation

Laparoscopic, Endoscopic and Robotic Surgery
Objective: Female sterilization is a common contraceptive method, but with changing family dynamics, an increasing number of women seek to restore fertility after tubal sterilization.
Shanliang Shang, Wenhua Liu, Xiaona Lin
doaj   +1 more source

Laparoscopic Excision of Coexisting Left Tubal and Right Pseudotubal Pregnancy after Conservative Management of Previous Ectopic Pregnancy with Methotrexate: An Unusual Clinical Entity

Case Reports in Surgery, 2015
Tubal pregnancy concerns 97% of all ectopic pregnancies. Treatment can be either surgical (salpingostomy or salpingectomy) or medical (methotrexate administration).
Panayotis Xiromeritis, Chrysoula Margioula-Siarkou, Dimosthenis Miliaras, Ioannis Kalogiannidis   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Fertility Outcome after Tubal Flushing in Patients Undergoing Salpingectomy for Tubal Ectopic Pregnancy: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology
Background: To examine the effect of tubal flushing on the fertility outcome of patients with tubal ectopic pregnancy (EP) undergoing salpingectomy.
Wenying Zhang, Jing Liu, Jiajun Shen, Yan Song, Yu Liu, Chengbin Ma   +5 more
doaj   +1 more source

Spontaneous ruptured bilateral tubal ectopic pregnancy following natural conception: A rare case report

Journal of Human Reproductive Sciences, 2021
Ectopic pregnancy complicates 0.25%–2% of all pregnancies and is one of the most common causes of first-trimester maternal mortality in developing countries due to late diagnosis.
Amobi Bobbie Chukwujioke Iwe, Johnbosco Ifunanya Nwafor, Obiora Godfrey Asiegbu, Joshua Adeniyi Adebayo, Bridget Nkiruka Uche-Nwidagu, Vincent Chidiebere Ali   +5 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source