Results 71 to 80 of about 44,269 (299)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

SALPINGOSCOPY – A USEFUL TOOL IN THE DIAGNOSIS OF PATHOLOGICAL CHANGES IN THE TUBE

Zdravniški Vestnik, 2003
Background. To confirm the hypothesis that the incidence of pathological changes of the mucosa in the contralateral tube is higher in women with tubal pregnancy than in fertile women.
Irma Virant, Tomaž Tomaževič
doaj  

Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities [PDF]

, 2015
Background : Observational studies suggest higher pregnancy rates after the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions, which are detectable in 10% to 15% of women seeking treatment for ...
Bosteels, Jan, Broekmans, Frank J, D'Hooghe, Thomas M, Kasius, Jenneke, Mol, Ben Willem J, Weyers, Steven   +5 more
core   +2 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Predicting live birth, preterm and low birth weight infant after in-vitro fertilisation: a prospective study of 144018 treatment cycles [PDF]

, 2011
Background The extent to which baseline couple characteristics affect the probability of live birth and adverse perinatal outcomes after assisted conception is unknown.
A Nyboe Andersen, A Nyboe Andersen, A Templeton, AM Stolwijk, AM Stolwijk, CC Hunault, CC Hunault, CW Redman, D Bodri, Debbie A. Lawlor, DO Mook-Kanamori, E Leushuis, E Villamor, E von Elm, ER DeLong, ES Draper, G Palermo, GA Colditz, GC Smith, I Craft, JJ Morrison, JK Min, JL Evers, JMJ Smeenk, KG Nygren, LB Romundstad, M Cooley, MJ Pencina, N Johnson, Nicholas M. Fisk, O Basso, P Stutchfield, R Bukowski, RA Jackson, RJ Paulson, Scott M. Nelson, VM Allen, YT van der Schouw   +37 more
core   +4 more sources

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

A Rare Case of Isolated torsion of Haematosalphinx Presenting as Acute Abdomen During Pregnancy [PDF]

, 2012
Isolated fallopian tubal torsion is a rare non obstetric cause for pain abdomen during pregnancy.We report a case of a 34 year old second gravida who presented with history of amennorrhoe of 7 months, colicky pain in the left iliac fossa , with 2 ...
Padmalatha, VV, Poornima, M, Rao, SR, Shakuntala, PN   +3 more
core