Results 31 to 40 of about 120,216 (242)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Pathway linking unwanted pregnancy to low birth weight in Indonesia: A conditional mediation analysis

Heliyon
Unwanted pregnancies resulting in detrimental consequences for both the mother and the child, including low birth weight, pose a remarkable challenge in developing countries.
Dedik Sulistiawan, Chyi-Huey Bai
doaj   +1 more source

Pengaruh Promosi Kesehatan Tentang Kehamilan Tidak Diinginkan Terhadap Tingkat Pengetahuan Dan Sikap Remaja Di Sma Sandika [PDF]

, 2018
Background: Adolescents at the age of 13-20 years begin to recognize the opposite sex and there is a desire to fulfill their sexual needs, so that it can cause unwanted pregnancy. The prevalence of unwanted pregnancies in the world in 2012 was 85%.
Febriana, Tria
core  

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Correlates of Unwanted Pregnancy among Pregnant Women attending Medical and Health Centers in Semnan, Iran [PDF]

حیات, 2009
Background & Aim: Unwanted pregnancy is one of the most important causes of mother and child mortality. It may end up to illegal abortion and result in inevitable physical and psychological consequences.
* H (Ph.D) Sanaie Nasab, ** H (MSc.) Rashidi Jahan, *** R (Ph.D) Tavakoli, **** HR (Ph.D) - Tavakoli, ***** F (Ph.D). Amin Shokravi   +4 more
doaj   +2 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Perilaku Seksual Pranikah Berisiko Terhadap Kehamilan Tidak Diinginkan PadaRemaja SMKN Tandun Kabupaten Rokan Hulu [PDF]

, 2016
Increasing premarital sexual behavior among college students today needs special attention from all parties, including the universities. The case of an unwanted pregnancy, abortion, and sexually transmitted infections premarital are more common among ...
Wulandari, S. (Sri)
core  

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

UNWANTED PREGNANCY AND ABORTION

نشریه پرستاری ایران, 2001
Background: Illegal abortion is one of the most important leading factors for maternal mortality and morbidity worldwide. Abortion may cause infertility, hemorrhage, sepsis, intra-abdominal injuries or genitourinary infections.
Jahanfar, S, Ramazai,- Tehrani, F, Sadat- Hashemi, M   +2 more
doaj