Results 121 to 130 of about 81,186 (261)

Hypoxia modulates P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) drug transporters in brain endothelial cells of the developing human blood-brain barrier

Heliyon
P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) multidrug resistance (MDR) transporters are localized at the luminal surface of the blood-brain barrier (BBB).
Hafsah Mughis, Phetcharawan Lye, Guinever E. Imperio, Enrrico Bloise, Stephen G. Matthews   +4 more
doaj   +1 more source

Characterisation of the 3' region of the PSG11 gene : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Palmerston North, New Zealand [PDF]

, 1995
Appendix : Content removed due to copyright restrictions. 1. Bichimica et Biophysica Acta l2l9 (1994) 195-t97 Sequence of a novel pregnancy-specific B ...
McLenachan, Patricia Ann
core  

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Antiphospholipid Syndrome Antibodies — Snippets from the Laboratory

Proceedings of Singapore Healthcare, 2013
Antiphospholipid (aPL) antibodies refer to antibodies associated with the clinical syndrome of vascular thrombosis and/or pregnancy morbidity, termed as aPL syndrome (APS).
Justin Hung Tiong Tan MBBS, MRCPCH (UK), Cecilia Ngan MBBS, MSc, FRCPA, FAMS, Thaschawee Arkachaisri MD, FACR   +2 more
doaj   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Workshop Report: Proposed Nomenclature for the Carcinoembryonic Antigen (CEA) Gene Family. [PDF]

, 1990
Barnett, T., Zimmermann, Wolfgang
core   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Polyhedral Oligomeric Silsesquioxane Based Material for Tumor Heterogeneity MR Visualization and Precise Treatment

SusMat, EarlyView.
ABSTRACT Malignant tumors whose mortality rates up to 97% possess high heterogeneity that leads to rapid growth, strong invasive capability, and low drug sensitivity. Quantitative magnetic resonance imaging enables direct visualization of tumors. However, gadolinium‐based contrast agents used in clinical practice have significant drawbacks of short ...
Xiaochuan Geng, Zhiguo Zhuang, Jiahui Zhang, Xinxin Zhao, Haiying Lyu, Zi Fu, Xi Liu, Ting Qian, Zhihui Li, Tongtong Chen, Qing Zhang, Yan Zhou, Yong Lu, Gang Wei   +13 more
wiley   +1 more source