Results 51 to 60 of about 2,632,772 (344)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Placental Inflammasome mRNA Levels Differ by Mode of Delivery and Fetal Sex

Frontiers in Immunology, 2022
Parturition signals the end of immune tolerance in pregnancy. Term labour is usually a sterile inflammatory process triggered by damage associated molecular patterns (DAMPs) as a consequence of functional progesterone withdrawal.
Anya L. Arthurs, Melanie D. Smith, Mhyles D. Hintural, James Breen, Dylan McCullough, Francesca I. Thornton, Shalem Y. Leemaqz, Gustaaf A. Dekker, Tanja Jankovic-Karasoulos, Claire T. Roberts   +9 more
doaj   +1 more source

Thrombophilia and pregnancy [PDF]

Reproductive Biology and Endocrinology, 2003
Preeclampsia, intrauterine growth restriction and placental abruption greatly contribute to maternal and fetal morbidity and mortality. Thrombophilia is an inherited or acquired condition that predisposes individuals to venous and/or arterial thrombosis. Recently, three important inherited thrombophilias have been discovered.
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Successfully conservative management of the uterus in acute pulmonary embolism during cesarean section for placenta previa: a case report from Tu Du Hospital, Vietnam and literature review

International Journal of Emergency Medicine
Background Cardiopulmonary collapse is a catastrophic event in cesarean section, which leads to adverse outcomes for both the mother and the fetus. Pulmonary embolism is one of the rare etiologies of this entity.
Anh Dinh Bao Vuong, Thanh Hai Pham, Van Hoang Bui, Xuan Trang Nguyen, Ngoc Bich Trinh, Yen Oanh Ngoc Nguyen, Dang Khoa Tran Le, Phuc Nhon Nguyen   +7 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Maternal haemoglobin concentrations before and during pregnancy and stillbirth risk: A population-based case-control study [PDF]

, 2016
Background: Results of previous studies on the association between maternal haemoglobin concentration during pregnancy and stillbirth risk are inconclusive. It is not clear if haemoglobin concentration before pregnancy has a role.
Aarabi, M., Bahmanyar, S., Cnattingius, S., Maghsoudlou, S., Montgomery, S.M., Semnani, S., Stephansson, O.   +6 more
core  

Efficacy of Achieving Pregnancy with Fertility-Focused Intercourse [PDF]

, 2014
Purpose: To compare pregnancy rates when women have intercourse on self-estimated high and peak fertile days and when they only have intercourse on low fertile days during the fertile window (FW).
Fehring, Richard, Mu, Qiyan
core   +2 more sources

Nausea and vomiting in pregnancy (NVP) is not just 'Morning Sickness' : data from a prospective cohort study [PDF]

, 2020
Background: Nausea and vomiting in pregnancy is usually called ‘morning sickness’. This is felt by sufferers to trivialise the condition. Symptoms have been described as occurring both before and after noon, but daily symptom patterns have not been ...
Gadsby, Roger, Hutton, Jane L., Ivanova, Diana, Johnson, Sarah, Trevelyan, Emma   +4 more
core   +1 more source